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Database: UniProt
Entry: F4RCD0_MELLP
LinkDB: F4RCD0_MELLP
Original site: F4RCD0_MELLP 
ID   F4RCD0_MELLP            Unreviewed;       856 AA.
AC   F4RCD0;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   07-JUN-2017, entry version 24.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=MELLADRAFT_115620 {ECO:0000313|EMBL:EGG09981.1};
OS   Melampsora larici-populina (strain 98AG31 / pathotype 3-4-7) (Poplar
OS   leaf rust fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC   Pucciniomycetes; Pucciniales; Melampsoraceae; Melampsora.
OX   NCBI_TaxID=747676 {ECO:0000313|Proteomes:UP000001072};
RN   [1] {ECO:0000313|Proteomes:UP000001072}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=98AG31 / pathotype 3-4-7 {ECO:0000313|Proteomes:UP000001072};
RX   PubMed=21536894; DOI=10.1073/pnas.1019315108;
RA   Duplessis S., Cuomo C.A., Lin Y.-C., Aerts A., Tisserant E.,
RA   Veneault-Fourrey C., Joly D.L., Hacquard S., Amselem J.,
RA   Cantarel B.L., Chiu R., Coutinho P.M., Feau N., Field M., Frey P.,
RA   Gelhaye E., Goldberg J., Grabherr M.G., Kodira C.D., Kohler A.,
RA   Kuees U., Lindquist E.A., Lucas S.M., Mago R., Mauceli E., Morin E.,
RA   Murat C., Pangilinan J.L., Park R., Pearson M., Quesneville H.,
RA   Rouhier N., Sakthikumar S., Salamov A.A., Schmutz J., Selles B.,
RA   Shapiro H., Tanguay P., Tuskan G.A., Henrissat B., Van de Peer Y.,
RA   Rouze P., Ellis J.G., Dodds P.N., Schein J.E., Zhong S., Hamelin R.C.,
RA   Grigoriev I.V., Szabo L.J., Martin F.;
RT   "Obligate biotrophy features unraveled by the genomic analysis of rust
RT   fungi.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:9166-9171(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GL883096; EGG09981.1; -; Genomic_DNA.
DR   RefSeq; XP_007407035.1; XM_007406973.1.
DR   EnsemblFungi; EGG09981; EGG09981; MELLADRAFT_115620.
DR   GeneID; 18925651; -.
DR   KEGG; mlr:MELLADRAFT_115620; -.
DR   EuPathDB; FungiDB:MELLADRAFT_115620; -.
DR   InParanoid; F4RCD0; -.
DR   KO; K02154; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000001072; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001072};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001072};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    434    463       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    484    503       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    565    584       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    596    616       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    658    678       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    789    814       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      103    144       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   856 AA;  95778 MW;  D408969AC52B6575 CRC64;
     MSSLLRSEAM SLVQIYIPND VAHPTVAELG ELGRVQFKDL NTDLNPFQRA YVAEIRRLDE
     MTRRLNFFNS LLDSENIAAR SLTVSSSTHL LAPTAGSNYA AVLDSLDSEL KDHEIRLQTM
     NSSYEQLRTR LGELEEARHV LRETAIFFER ANHHPSERRV SDVDLDDDRA GLLDNAAEEG
     RGGRSDETSG NTAFELEFVA GTIDRTRMPT FERVLWRVLR GNLYLNWAEI EEPLTSSVAA
     LSPSASQADQ EKASAVRKVV FIIFAHGDEL LSKIRKIADS MGANVIPVEA NASAREASLR
     EVTSRIEDIS SVLYNTNQTR RQALSNIAES IAGWWAVVRK EKRIYATLNL FQYDEGRRTL
     ISEGWIPTRD ITAVQQALNR ATENAGTTVP AILHELRTSA KPPTFHRTNK FTEGFQAIVD
     AYGIASYQEI NPALFTIITF PFLFAVMFGD IGHGLIMFLA ALAMVMNEKK LAKVKDEIFS
     MFYFGRYIIL LMGAFAVFTG FIYNDIFSLS LTLAPSAWKW PEHISNGTVT AEPTAYRYPF
     GIDPNWHGAE NNLIFTNSLK MKMSIILGVI HMSFAICLQV PNHLFFGRKS SIWAEFLPQI
     LFMESIFGYL VLTILYKWSI DWSQPGMGNP PNLLNMLIYM FLSPGTVDPD EQLYTGQAFI
     QVFLLLLALI CIPWMLCVKP YLEYKEHEKI VSQGYGIVGG HGDGAGGRSS FDAEEEEAGH
     VAAHGSDDEH GFDMGDIIIH QSIHTIEFAL GCISNTASYL RLWALSLAHA QLSEVLWSMT
     MKLAFGVEGV TGIVFTVILF AMWITLTVAI LIVMEGLSAF LHALRLHWVE SNGKHYEGAG
     YQFEPLSFVG IDEGYD
//
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