ID F4T6Z5_ECOLX Unreviewed; 2255 AA.
AC F4T6Z5;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=ECIG_05142 {ECO:0000313|EMBL:EGI13378.1};
OS Escherichia coli M605.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=656417 {ECO:0000313|EMBL:EGI13378.1, ECO:0000313|Proteomes:UP000004710};
RN [1] {ECO:0000313|EMBL:EGI13378.1, ECO:0000313|Proteomes:UP000004710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M605 {ECO:0000313|EMBL:EGI13378.1,
RC ECO:0000313|Proteomes:UP000004710};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Escherichia coli M605.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL883928; EGI13378.1; -; Genomic_DNA.
DR RefSeq; WP_001038185.1; NZ_GL883928.1.
DR HOGENOM; CLU_001065_0_0_6; -.
DR Proteomes; UP000004710; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR41313; ADENINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR41313:SF1; DNA METHYLASE ADENINE-SPECIFIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 841..1126
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1383..1568
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT COILED 1199..1229
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1620..1650
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1676..1703
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2255 AA; 251640 MW; D8F4AE4E3A81CF1F CRC64;
MNKLSMGVFR CSSVSEILKY IRAITSHRAP IRYGVEKVEG KSYDRLRREA NQKAIDLLNS
LVDGATLTDE QRQILAGYTG EGGIGGSVSE YYTPKPIAEG VWEIMKLYGA DVGNTLEPSA
GTGVFNETKP VGTVMTATEI SSVSGRINQL LHPEDSVQIS PFEQLAVSTP NDSFDHVVGN
VPFGGRDNTR NIDKPYAEET DMGSYFMLRM LDKIKPGGFM CVIVPPSIVS GSNMKRLRLR
LSRKAEFLGA HRLPTGTFDA NGTSTVVDVV LMRKHPAEMA EKIPLVDEGT LESANVLWPT
FISGKWFEKD GRRFVHGTQE KGFQGRIEVR ADGQIDNQAL KAKLIHRFES RIDWSLLNMA
EPSPTADVVD EGEMRLINGV WQKYAGGRWI EADAGKELKI DAASYGANSW EALQRNLTTT
EGRLGMTFTQ MANVRDKYTT SISDDMVQLV DWINSQPEKY RERLYRGAMI GRMLIEYQDM
KAAGHSAEQI EQQRLSLVSR LQAEIDRFGN PGRGPIAKLS GSGARAWFAF RGAIKLDGTI
SDELTGKLVT HDSSASYDST SYQDTLRYLY SDLTRDPIQL DDFRLAFTGE LPASDEELLN
LLASTPGIAV SPYGGIVPFA RATSGDINEI VAPKQEFLAT LPDGPVKNNV LNQLAAIEEK
RIKTPAENIR FKLNSRWFDR SVILEFLQEN GYPDLRYVQS VQLEGDEMVS DTYHGGDGLF
VGHRYGVVQR KDKETGEIRY EWDRKSGENA TGFPAQLEKY LNGARIGGKD SATANGYREQ
MALLEDQFNK WIKTHDRYDE LVAKYNDVFN SNIPYEHSGD PLGLKGLSGK RQPFDYQNSE
VRRLSEDGRG ILGFGTGLGK TTTALALEAF NYENGRSTRT LYVVPKSVLE NWYYEAKEFL
SEEAFSNYLF VGLDVLMDGD QIRQVPVLDE NGKAVVGADG TPVMRDALKL ADEATITARI
NAIPHSNYRA VVLTKEQYFR LPLRDETVDE HAQDMLLDFV AAGRVASAMD SDSHRKEAAR
RRILSEYSDT GTEKSEKYPY FEDMGFDSVI VDEGHNYRNS YKNGREASQL AYLPTSAVAQ
SARDMAIKNA YLMKKNGGRG PVLLTATPVV NTPIDAYNML SHVLPKEYWQ KMGIYGPDDF
VKFFGKTRLE TVQKISGEVE EKMALVGFEN LDALRGIFHR WTTLKTAEDV KDTVEIPELD
EHQQDAPLTE EQLAAYEELR QQAEAAAKAN NGVTTSVNED GVIEHEKARP IFSIIRDMDR
VCTDMDLYYR RITYRFLPEY ADAVQQLADS LPKQATSEDD DSDDAITQQS QYSLIDKGEF
IQLQVPEAFE QEVNKRLARF GIDEQTVTHP VTPKYAKLIA TLKEFFPEGK QIIFTDEKTQ
HQKLKRIICN ALNLEPSKVG ILNAQTVAEA GKTGKKLKAV KPPKELPDEP TDAQLAKYNE
QMALYDAYIA QQNEMSLGGL EKIAADFQEG RTPIIICNKK AEVGINLHRG TTDIHHLTLP
WTPASIAQRN GRGARVGSNR ASVRVHYYCG KGSFDEYRLK TLKRKAGWIS DILRSDKSEM
ENADANDMIE MQMYTAKDDG ERLAMMQVQM DKAKAAQRAR QKEQATIDLQ NYIKAQHAAG
EDVEVLTAEL ERNKAELEKT TAEVAKFKQA VMAKAADNAD WKARWGSVHN ADRMLLARYR
ASLKNAIQQK ANISQAISRY EKLLNRTQKA ATDIKRLRPL VEDAINKGIL DVDPDLVNHA
SEFLVIGDRS WRVGQYYDFA GDIVRIKSLD FDSQRADVEI IFTFKGTKSG NWDVKTLDKQ
VDVTPNEDAV MQKISGGVSI AGINDIISCD DFYRFQQRGM IKITDSYGVQ TTESGYSIDF
VGTYTDPLKH AVYPDRRDGA LKSSIAKWVL GMMSEGNNRQ IRLAEVFLTE LFGSNYGDVI
ASYGDTLSPE AIQEKIADAI ARMPEKTSQG ATRNGDSELE VTNAIFGTHE FRASDYEITT
AQFGTIGIYS NKDEVKQAMD AASARIAAER KTNLNHAVAA LTQSWVTAIR EAATTGKITP
AIADVVNDGS KFMDAYQMDA VKLPSAYGQL SYRMTYNLVS MFSDLAILGL VDLNEVTPEL
LSMRKNHVEI LQRINTVLAG RTDEEKQADA DRINLALGNI TEEEIAARNE KQEELSSIQG
DATSIAQSLG LNYRVSTADL KMMYAPKFAA GEVFGLQEAS GMKGILFRAK DAIKAKFGAR
WLPAKAKNSD FPGNWWIIET KHNVADVMAV IQQYA
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