ID F4TE06_ECOLX Unreviewed; 395 AA.
AC F4TE06;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Secretion protein HlyD {ECO:0000313|EMBL:EGI21665.1};
GN ORFNames=ECJG_04515 {ECO:0000313|EMBL:EGI21665.1};
OS Escherichia coli M718.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=656419 {ECO:0000313|EMBL:EGI21665.1, ECO:0000313|Proteomes:UP000002790};
RN [1] {ECO:0000313|EMBL:EGI21665.1, ECO:0000313|Proteomes:UP000002790}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M718 {ECO:0000313|EMBL:EGI21665.1,
RC ECO:0000313|Proteomes:UP000002790};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Escherichia coli M718.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; GL884119; EGI21665.1; -; Genomic_DNA.
DR RefSeq; WP_000928803.1; NZ_GL884119.1.
DR AlphaFoldDB; F4TE06; -.
DR HOGENOM; CLU_018816_14_1_6; -.
DR Proteomes; UP000002790; Unassembled WGS sequence.
DR GO; GO:0019898; C:extrinsic component of membrane; IEA:InterPro.
DR GO; GO:1990195; C:macrolide transmembrane transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 6.10.140.1990; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR030190; MacA_alpha-hairpin_sf.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF33; EFFLUX PROTEIN; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 48..263
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 99..181
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 395 AA; 43424 MW; 18A33CA3E1412D9C CRC64;
MLMKYISHRA IICTLTLLII IITVLFTFLR SSDVPEYITA PVRKGDIENS VLATGRIDAI
ERVNVGAQVS GQLKSLKVKQ GDHVTKGQLI AEIDDLPQCN DLRNAEAALN EVKAELQSKQ
ALLKQAELRF KRQLRMLREN ASSHEDFESA EAMLATTRAE LHSLNAKLVQ AQIEVDKKKL
ALEYTRVVAP MDGIVIAIVT QQGQTVNSNQ SAPTIIKLAR LDVMTIKAQI SEADITRISV
GQKARFSIFS EPDKHYSATL RAVELAPESV MKDDSLASNT SASGSGTSNA SVYYNALFDV
PNPENRLRIA MTAQVTLITD EAQNTLLVPI QAVHRNEGKK KQVLVLAADG RLEPRNVKTG
ITNSVDIQIL EGLNVGENVV LSLPDKKEPE ERIML
//
