ID   F4TMA0_ECOLX            Unreviewed;       463 AA.
AC   F4TMA0;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   SubName: Full=Putative purine permease YicE {ECO:0000313|EMBL:EGI19380.1};
GN   ORFNames=ECJG_03353 {ECO:0000313|EMBL:EGI19380.1};
OS   Escherichia coli M718.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=656419 {ECO:0000313|EMBL:EGI19380.1, ECO:0000313|Proteomes:UP000002790};
RN   [1] {ECO:0000313|EMBL:EGI19380.1, ECO:0000313|Proteomes:UP000002790}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M718 {ECO:0000313|EMBL:EGI19380.1,
RC   ECO:0000313|Proteomes:UP000002790};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q.,
RA   Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Escherichia coli M718.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR   EMBL; GL884131; EGI19380.1; -; Genomic_DNA.
DR   RefSeq; WP_001295238.1; NZ_GL884131.1.
DR   AlphaFoldDB; F4TMA0; -.
DR   SMR; F4TMA0; -.
DR   GeneID; 75202224; -.
DR   HOGENOM; CLU_017959_8_0_6; -.
DR   Proteomes; UP000002790; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   NCBIfam; TIGR00801; ncs2; 1.
DR   NCBIfam; NF037981; NCS2_1; 1.
DR   PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   PANTHER; PTHR42810:SF2; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        36..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        128..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        158..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        193..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        219..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        350..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        378..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        408..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        439..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   463 AA;  48868 MW;  868718559103456E CRC64;
     MSVSTLESEN AQPVAQTQNS ELIYRLEDRP PLPQTLFAAC QHLLAMFVAV ITPALLICQA
     LGLPAQDTQH IISMSLFASG VASIIQIKAW GPVGSGLLSI QGTSFNFVAP LIMGGTALKT
     GGADVPTMMA ALFGTLMLAS CTEMVISRVL HLARRIITPL VSGVVVMIIG LSLIQVGLTS
     IGGGYAAMSD NTFGAPKNLL LAGVVLALII LLNRQRNPYL RVASLVIAMA AGYALAWFMG
     MLPESNEPMT QELIMVPTPL YYGLGIEWSL LLPLMLVFMI TSLETIGDIT ATSDVSEQPV
     SGPLYMKRLK GGVLANGLNS FVSAVFNTFP NSCFGQNNGV IQLTGVASRY VGFVVALMLI
     VLGLFPAVSG FVQHIPEPVL GGATLVMFGT IAASGVRIVS REPLNRRAIL IIALSLAVGL
     GVSQQPLILQ FAPEWLKNLL SSGIAAGGIT AIVLNLIFPP EKQ
//