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Database: UniProt
Entry: F4V105_ECOLX
LinkDB: F4V105_ECOLX
Original site: F4V105_ECOLX 
ID   F4V105_ECOLX            Unreviewed;        97 AA.
AC   F4V105;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Negative regulator of flagellin synthesis {ECO:0000256|ARBA:ARBA00017823};
DE   AltName: Full=Anti-sigma-28 factor {ECO:0000256|ARBA:ARBA00030117};
GN   ORFNames=ECNG_03927 {ECO:0000313|EMBL:EGI41600.1};
OS   Escherichia coli TA280.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=656444 {ECO:0000313|EMBL:EGI41600.1, ECO:0000313|Proteomes:UP000004877};
RN   [1] {ECO:0000313|EMBL:EGI41600.1, ECO:0000313|Proteomes:UP000004877}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TA280 {ECO:0000313|EMBL:EGI41600.1,
RC   ECO:0000313|Proteomes:UP000004877};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q.,
RA   Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Escherichia coli TA280.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for the coupling of flagellin expression to
CC       flagellar assembly by preventing expression of the flagellin genes when
CC       a component of the middle class of proteins is defective. It negatively
CC       regulates flagellar genes by inhibiting the activity of FliA by
CC       directly binding to FliA. {ECO:0000256|ARBA:ARBA00024739}.
CC   -!- SIMILARITY: Belongs to the FlgM family.
CC       {ECO:0000256|ARBA:ARBA00005322}.
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DR   EMBL; GL884341; EGI41600.1; -; Genomic_DNA.
DR   AlphaFoldDB; F4V105; -.
DR   HOGENOM; CLU_149304_2_2_6; -.
DR   Proteomes; UP000004877; Unassembled WGS sequence.
DR   GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR   InterPro; IPR035890; Anti-sigma-28_factor_FlgM_sf.
DR   InterPro; IPR007412; FlgM.
DR   InterPro; IPR031316; FlgM_C.
DR   NCBIfam; TIGR03824; FlgM_jcvi; 1.
DR   Pfam; PF04316; FlgM; 1.
DR   SUPFAM; SSF101498; Anti-sigma factor FlgM; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis {ECO:0000256|ARBA:ARBA00022795};
KW   Cell projection {ECO:0000313|EMBL:EGI41600.1};
KW   Cilium {ECO:0000313|EMBL:EGI41600.1};
KW   Flagellum {ECO:0000313|EMBL:EGI41600.1};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          40..88
FT                   /note="Anti-sigma-28 factor FlgM C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04316"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   97 AA;  10355 MW;  30A0B463324FE34D CRC64;
     MSIDRTSPLK PVSTVQPRET TDAPVTNTRA AKTTASTSTS VTLSDAQAKL MQPGSSDINL
     ERVEALKLAI RNGELKMDTG KIADALINEA QQDLQSN
//
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