ID   F4VI90_ECOLX            Unreviewed;       485 AA.
AC   F4VI90;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Xanthine permease family protein {ECO:0000313|EMBL:EGI45018.1};
GN   ORFNames=ECPG_04164 {ECO:0000313|EMBL:EGI45018.1};
OS   Escherichia coli H591.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=656408 {ECO:0000313|EMBL:EGI45018.1, ECO:0000313|Proteomes:UP000004681};
RN   [1] {ECO:0000313|EMBL:EGI45018.1, ECO:0000313|Proteomes:UP000004681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H591 {ECO:0000313|EMBL:EGI45018.1,
RC   ECO:0000313|Proteomes:UP000004681};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q.,
RA   Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Escherichia coli H591.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR   EMBL; GL884456; EGI45018.1; -; Genomic_DNA.
DR   AlphaFoldDB; F4VI90; -.
DR   HOGENOM; CLU_017959_8_0_6; -.
DR   Proteomes; UP000004681; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   NCBIfam; TIGR00801; ncs2; 1.
DR   PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   PANTHER; PTHR42810:SF5; XANTHINE PERMEASE XANQ; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        43..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        75..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        135..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        206..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        270..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        357..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        385..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        443..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   485 AA;  51339 MW;  DC7461A71C41E5CA CRC64;
     MGIYFTNSDD QIYFKRSEGM SDINNAGSDL IFELEDRPPF HQALVGAITH LLAIFVPMVT
     PALIVGAALQ LSAETTAYLV SMAMIASGIG TWLQVNRYGI VGSGLLSIQS VNFSFVTVMI
     ALGSSMKSDG FHEELIMSSL LGVSFVGAFL VVGSSFILPY LRRVITPTVS GIVVLMIGLS
     LIKVGIIDFG GGFAAKSSGT FGNYEHLGVG LLVLIVVIGF NCCRSPLLRM GGIAIGLCVG
     YIASLCLGMV DFSSMRNLPL ITIPHPFKYG FSFSFHQFLV VGTIYLLSVL EAVGDITATA
     MVSRRPIQGE EYQSRLKGGV LADGLVSVIA SAVGSLPLTT FAQNNGVIQM TGVASRYVGR
     TIAVMLVILG LFPMIGGFFT TIPSAVLGGA MTLMFSMIAI AGIRIIITNG LKRRETLIVA
     TSLGLGLGVS YDPEIFKILP ASIYVLVENP ICAGGLTAIL LNIILPGGYR QENVLPGITS
     AEEMD
//