ID F4W7H7_ACREC Unreviewed; 585 AA.
AC F4W7H7;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Triokinase/FMN cyclase {ECO:0000256|ARBA:ARBA00018932};
DE EC=2.7.1.28 {ECO:0000256|ARBA:ARBA00012110};
DE EC=2.7.1.29 {ECO:0000256|ARBA:ARBA00012107};
DE EC=4.6.1.15 {ECO:0000256|ARBA:ARBA00012578};
DE AltName: Full=Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) {ECO:0000256|ARBA:ARBA00032426};
GN ORFNames=G5I_01393 {ECO:0000313|EMBL:EGI69850.1};
OS Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus
OS echinatior).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Acromyrmex.
OX NCBI_TaxID=103372 {ECO:0000313|Proteomes:UP000007755};
RN [1] {ECO:0000313|EMBL:EGI69850.1}
RP NUCLEOTIDE SEQUENCE.
RA Nygaard S., Zhang G.;
RT "The genome of the leaf-cutting ant Acromyrmex echinatior suggests key
RT adaptations to social evolution and fungus farming.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate +
CC H(+); Xref=Rhea:RHEA:13941, ChEBI:CHEBI:15378, ChEBI:CHEBI:17378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:59776, ChEBI:CHEBI:456216;
CC EC=2.7.1.28; Evidence={ECO:0000256|ARBA:ARBA00000031};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate +
CC H(+); Xref=Rhea:RHEA:15773, ChEBI:CHEBI:15378, ChEBI:CHEBI:16016,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57642, ChEBI:CHEBI:456216;
CC EC=2.7.1.29; Evidence={ECO:0000256|ARBA:ARBA00001015};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=FAD = AMP + H(+) + riboflavin cyclic-4',5'-phosphate;
CC Xref=Rhea:RHEA:13729, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692,
CC ChEBI:CHEBI:76202, ChEBI:CHEBI:456215; EC=4.6.1.15;
CC Evidence={ECO:0000256|ARBA:ARBA00000865};
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DR EMBL; GL887844; EGI69850.1; -; Genomic_DNA.
DR RefSeq; XP_011067578.1; XM_011069276.1.
DR AlphaFoldDB; F4W7H7; -.
DR STRING; 103372.F4W7H7; -.
DR EnsemblMetazoa; XM_011069276.1; XP_011067578.1; LOC105154032.
DR GeneID; 105154032; -.
DR KEGG; aec:105154032; -.
DR eggNOG; KOG2426; Eukaryota.
DR InParanoid; F4W7H7; -.
DR OrthoDB; 6043at2759; -.
DR Proteomes; UP000007755; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0034012; F:FAD-AMP lyase (cyclizing) activity; IEA:UniProtKB-EC.
DR GO; GO:0004371; F:glycerone kinase activity; IEA:InterPro.
DR GO; GO:0006071; P:glycerol metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.340; -; 1.
DR InterPro; IPR004006; DhaK_dom.
DR InterPro; IPR004007; DhaL_dom.
DR InterPro; IPR036117; DhaL_dom_sf.
DR PANTHER; PTHR28629; TRIOKINASE/FMN CYCLASE; 1.
DR PANTHER; PTHR28629:SF4; TRIOKINASE_FMN CYCLASE; 1.
DR Pfam; PF02733; Dak1; 1.
DR Pfam; PF02734; Dak2; 1.
DR SMART; SM01120; Dak2; 1.
DR SUPFAM; SSF82549; DAK1/DegV-like; 1.
DR SUPFAM; SSF101473; DhaL-like; 1.
DR PROSITE; PS51481; DHAK; 1.
DR PROSITE; PS51480; DHAL; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EGI69850.1};
KW Lyase {ECO:0000313|EMBL:EGI69850.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007755};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..338
FT /note="DhaK"
FT /evidence="ECO:0000259|PROSITE:PS51481"
FT DOMAIN 377..578
FT /note="DhaL"
FT /evidence="ECO:0000259|PROSITE:PS51480"
SQ SEQUENCE 585 AA; 63399 MW; AA7DA144D26923CB CRC64;
MATSKSLINL LDDAVFETLS GLSYTYPQLE HHASHRVVLS PDHRDRKDKV ALICGGGSGH
EPFAAGFVGS GMLTASVAGS IFTAPPSIHI TYALQCIAEN NKDGIVVVVP NYTGDRLNFG
IAIEKTRQAG VAVEEVIVDD DCSIPVNEQS VAGKRGLVGM LFVIKIAGAF AEKGFPLCEV
AEIARRVSQN TATYGIGLSA CAIPGQGLMF ELAQDEIECG MGVHGEAGYE RIKLRTASEL
VMLMLKRICE VLSLSTNDSV AVIVNNFGAL SQLEQGIIVY EVVNQLQKTG IQPVRVYSGV
LMTSLNSVGI HISLLKLTEN HGDVFVDCLD EKTTAPCWPG CTYSISSTST PLSTPLKDAK
KEKVEKIGIL LNVTDQRLIK LCLKNACIAI IEKEAYLNGL DRGCGDGDCG STLKRFANGI
LNNLENLSLS HPAALLLEIA NIAEECMGGT SGALYCLFFT TGAKMLASFR QEKDMRNVWF
CAFRSGLNCL EKYGRAKVGD RTMIDTMYAT YTTYEKLLKE CPSDFYEKIT AAAWEGCYST
RNMKPKAGRA SYIKQAQYLT EMDAGAYAAA IWIAAIVQTI THFKK
//
