ID F4W8S3_ACREC Unreviewed; 501 AA.
AC F4W8S3;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Muscarinic acetylcholine receptor DM1 {ECO:0000313|EMBL:EGI69564.1};
GN ORFNames=G5I_01855 {ECO:0000313|EMBL:EGI69564.1};
OS Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus
OS echinatior).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Acromyrmex.
OX NCBI_TaxID=103372 {ECO:0000313|Proteomes:UP000007755};
RN [1] {ECO:0000313|EMBL:EGI69564.1}
RP NUCLEOTIDE SEQUENCE.
RA Nygaard S., Zhang G.;
RT "The genome of the leaf-cutting ant Acromyrmex echinatior suggests key
RT adaptations to social evolution and fungus farming.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|ARBA:ARBA00010663, ECO:0000256|RuleBase:RU000688}.
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DR EMBL; GL887908; EGI69564.1; -; Genomic_DNA.
DR AlphaFoldDB; F4W8S3; -.
DR SMR; F4W8S3; -.
DR STRING; 103372.F4W8S3; -.
DR eggNOG; KOG4220; Eukaryota.
DR InParanoid; F4W8S3; -.
DR Proteomes; UP000007755; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0016907; F:G protein-coupled acetylcholine receptor activity; IEA:InterPro.
DR CDD; cd15301; 7tmA_mAChR_DM1-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000995; Musac_Ach_rcpt.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF268; MUSCARINIC ACETYLCHOLINE RECEPTOR DM1; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00243; MUSCARINICR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000007755};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 214..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 230..501
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 54..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..116
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 501 AA; 57168 MW; 7CA4740C63B47F5B CRC64;
MPCALNREVI ALHTWRNMHP STPLPQQQFD RLARDIELAA FDEESVAIMA VIDESTTTEA
VDEEEEEEEE EEEGGEEEAA AEEEEEEEGE GEEEEEEEEE DEDEENDDDE ENEEEEVVEK
GRDRDGSIGE GGAVRRIPVY GDEGYRKRAG RKKEREERGR EREREKRQGE RTRDSPSDMN
VTPMVEIPGN DNYSISNGLD CGGEPHQYAI WERVTIVVIA VILSLTTVVG NIMVMISFKI
DKNLQTISNY FLFSLAVADF AIGLISMPLF TIYTVLGYWP LGPLVCDTWL ALDYLASNAS
VLNLLIISFD RYFSVTRPLT YRAKRTTFKA SVMIGSAWGI SLLLWPPWIY AWPYIEGQRT
VPKASCYIQF IETNHYITFG TAIAAFYVPV MIMTFLYWRI WLETKKRQKD LPNLQAGKQD
ASKRSNSSDE VLDMEESRRQ RSESSTADDV SHATHIAVSY IDKHYPQYKS VSIVVTLSVN
AITPSGVTLH VYLFARLHKC R
//
