ID F4WLB4_ACREC Unreviewed; 313 AA.
AC F4WLB4;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Alcohol dehydrogenase [NADP+] A {ECO:0000313|EMBL:EGI65077.1};
GN ORFNames=G5I_06538 {ECO:0000313|EMBL:EGI65077.1};
OS Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus
OS echinatior).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Acromyrmex.
OX NCBI_TaxID=103372 {ECO:0000313|Proteomes:UP000007755};
RN [1] {ECO:0000313|EMBL:EGI65077.1}
RP NUCLEOTIDE SEQUENCE.
RA Nygaard S., Zhang G.;
RT "The genome of the leaf-cutting ant Acromyrmex echinatior suggests key
RT adaptations to social evolution and fungus farming.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL888207; EGI65077.1; -; Genomic_DNA.
DR RefSeq; XP_011055124.1; XM_011056822.1.
DR RefSeq; XP_011055125.1; XM_011056823.1.
DR AlphaFoldDB; F4WLB4; -.
DR STRING; 103372.F4WLB4; -.
DR EnsemblMetazoa; XM_011056822.1; XP_011055124.1; LOC105146509.
DR EnsemblMetazoa; XM_011056823.1; XP_011055125.1; LOC105146509.
DR GeneID; 105146509; -.
DR KEGG; aec:105146509; -.
DR eggNOG; KOG1577; Eukaryota.
DR InParanoid; F4WLB4; -.
DR OrthoDB; 890110at2759; -.
DR Proteomes; UP000007755; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd19116; AKR_AKR2E1-5; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR044488; AKR2E.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR PANTHER; PTHR11732:SF507; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007755}.
FT DOMAIN 21..289
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 51
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 113
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 80
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 313 AA; 35283 MW; 1890EE6A298A2849 CRC64;
MAGIPTITFS NGYKMPILGL GTYKSQMGDV KRAVKDAIDL GYRHIDTAFL YGNEKEIGEA
IRDKIKDGSV TREDLFITTK LWNNFHKEEQ VVPACKQSLA NLGLDYVDLF LVHWPFAFKE
GDDVWPLDAA GNLCDSDIDY LETWKGMEEC VHQGLTRSIG ISNFNSEQIT RLLKSAKIAP
VNNQIEVNVN VNQEKLIDFC KKHDITVTAY SPLGQPGNVS GIDNKLDNPI ILQLAKKYNK
TSAQIALRYV YQHGTAPIPK SVTKSRIKEN MEIFDFTLTS DEMNAIRKLG TGQRVAFFTP
AKNFKYFPFN IPF
//
