ID F4XEZ0_9FIRM Unreviewed; 551 AA.
AC F4XEZ0;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF0866_02163 {ECO:0000313|EMBL:EGJ46010.2};
OS Ruminococcaceae bacterium D16.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae.
OX NCBI_TaxID=552398 {ECO:0000313|EMBL:EGJ46010.2, ECO:0000313|Proteomes:UP000002801};
RN [1] {ECO:0000313|Proteomes:UP000002801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D16 {ECO:0000313|Proteomes:UP000002801};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Gevers D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Borenstein D., Chapman S.B., Chen Z., Engels R.,
RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Mehta T.,
RA Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T.D.,
RA Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C.,
RA Sibley C.D., White A.P., Crowley S., Surette M.G., Strauss J.C.,
RA Ambrose C.E., Allen-Vercoe E., Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridium sp. D5.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EGJ46010.2, ECO:0000313|Proteomes:UP000002801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D16 {ECO:0000313|EMBL:EGJ46010.2,
RC ECO:0000313|Proteomes:UP000002801};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Sibley C.D., White A.P.,
RA Crowley S., Surette M.G., Strauss J.C., Ambrose C.E., Allen-Vercoe E.,
RA Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Ruminococcaceae bacterium D16.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGJ46010.2}.
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DR EMBL; ADDX02000001; EGJ46010.2; -; Genomic_DNA.
DR AlphaFoldDB; F4XEZ0; -.
DR STRING; 552398.HMPREF0866_02163; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_12_1_9; -.
DR OrthoDB; 1725043at2; -.
DR Proteomes; UP000002801; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 2.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 2.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 2.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF33; EFFLUX PROTEIN; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF13437; HlyD_3; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR PRINTS; PR01490; RTXTOXIND.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002801};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 107..140
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT DOMAIN 321..458
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 323..350
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 551 AA; 57231 MW; 4398024A2C45D590 CRC64;
METKEQLQTA PEVPVIADAP EQDSTPTWKA PKKKRRWPKV VIAVLLVLAA LFFFVIRPML
GAGKELLAGA YLTSTAQMQE MTVSVSSTGT IQPIDSYNVS GMVTGEVLEA PFEVGDQVEK
GDVLYRIDPG SAETALQQAQ LSVQQAQLNY DSIVDGLNPK ASGAGVVQKL HVKKGDLVSA
GSPIADISDT STMTLTVPFQ SADAQRIAVG SSAQVTLAGT LETLTGTVES VANADLVGNG
GALVRQVKIR VQNPGALTTS TTATAKVGSI ACAGSGTFEA NLTQTVVATG SGEVVSLNVS
AGSRVSAGQV LATLGGSSAQ TSLENASISL QNAQLSLQNA QDALDNYTIT APISGTVIEK
NFKAGDTIDN NSLTAAGGTL AVLYDMSTLT FEMKIDEKDI NKVQVGQEVT ITADAVEGVT
FSGVVDTVNI NGTTVSGQTN YPVTVVINDP QDLKPGMNVS ADIIVERAGT VLCVPVDAVN
RGSDKPTVQV AQEGALDENG NVVDPSKLET REVTLGRNDN DNIEITSGLS EGEIVVWVNE
VSNPFAAMMG M
//
