ID F4Y2F2_9CYAN Unreviewed; 509 AA.
AC F4Y2F2;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=RND family efflux transporter, MFP subunit {ECO:0000313|EMBL:EGJ28796.1};
GN ORFNames=LYNGBM3L_69000 {ECO:0000313|EMBL:EGJ28796.1};
OS Moorena producens 3L.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Oscillatoriaceae; Moorena.
OX NCBI_TaxID=489825 {ECO:0000313|EMBL:EGJ28796.1, ECO:0000313|Proteomes:UP000003959};
RN [1] {ECO:0000313|Proteomes:UP000003959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3L {ECO:0000313|Proteomes:UP000003959};
RX PubMed=21555588; DOI=10.1073/pnas.1101137108;
RA Jones A.C., Monroe E.A., Podell S., Hess W.R., Klages S., Esquenazi E.,
RA Niessen S., Hoover H., Rothmann M., Lasken R.S., Yates J.R.III.,
RA Reinhardt R., Kube M., Burkart M.D., Allen E.E., Dorrestein P.C.,
RA Gerwick W.H., Gerwick L.;
RT "Genomic insights into the physiology and ecology of the marine filamentous
RT cyanobacterium Lyngbya majuscula.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:8815-8820(2011).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; GL890971; EGJ28796.1; -; Genomic_DNA.
DR RefSeq; WP_008190564.1; NZ_MKZR01000001.1.
DR AlphaFoldDB; F4Y2F2; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_14_4_3; -.
DR OrthoDB; 529856at2; -.
DR Proteomes; UP000003959; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 2.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 2.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF15; HLYD FAMILY OF SECRETION PROTEINS; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..141
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT DOMAIN 297..422
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 124..218
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 509 AA; 55023 MW; EEFE20133E3C0459 CRC64;
MEPVNPQVSN HYQPDSNSQS QEETKAKSSA WLLTVLFLVG GLALLQISTV PEPPVAQTKT
KQTPPRPVET IPLTLGKGIK RIQLLGEVEA SEKITIKSQV DGVIQQVKVR EGDRVKPGMT
IAILDGADQQ LALAQAKARL AQEKSNLARL QVGTRPEILA QRQAELDAAK AREQEAKDNL
DGMIAVQPNL IAQRQAELDG AQAREQEAKD NLKRIEALTL EGALSERAKV EAEKAADAAT
SERLRAQAAL SAEQTKTQQE IAEARSTVDA TISERLRIAA LLAEAQVGPT QEEIDAQKGV
VAAAVAAVEQ AQLASERATI KAPIAGVVQS RQVDTGNYVE GGDAIITLVN NAQFDIFLQV
PEKFTNQVKP GMYVELTAPR SLPNWQQRAQ ITSVVPTANA NSRRQLVRVN LNNPPKDLLA
GMGIEATLDL PIDVDPSFVI PRDAIIKRKN QSLIYTIYQD KAQEFTVEIL ADMGEKLLIT
NQKLQANQPL VVSGGEGLKN GAPVKITSP
//
