ID F4YYF9_ORITS Unreviewed; 467 AA.
AC F4YYF9;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Probable periplasmic serine endoprotease DegP-like {ECO:0000256|ARBA:ARBA00013958};
DE EC=3.4.21.107 {ECO:0000256|ARBA:ARBA00013035};
DE AltName: Full=Protease Do {ECO:0000256|ARBA:ARBA00032850};
GN Name=htrA {ECO:0000313|EMBL:ADO30456.1};
GN ORFNames=FPW1038_00153 {ECO:0000313|EMBL:SPM45301.1};
OS Orientia tsutsugamushi (Rickettsia tsutsugamushi).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Orientia.
OX NCBI_TaxID=784 {ECO:0000313|EMBL:ADO30456.1};
RN [1] {ECO:0000313|EMBL:ADO30456.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FPW1038 {ECO:0000313|EMBL:ADO30456.1};
RX PubMed=23590326; DOI=10.1089/vbz.2012.1112;
RA Jiang J., Paris D.H., Blacksell S.D., Aukkanit N., Newton P.N.,
RA Phetsouvanh R., Izzard L., Stenos J., Graves S.R., Day N.P., Richards A.L.;
RT "Diversity of the 47-kD HtrA nucleic acid and translated amino acid
RT sequences from 17 recent human isolates of Orientia.";
RL Vector Borne Zoonotic Dis. 13:367-375(2013).
RN [2] {ECO:0000313|EMBL:SPM45301.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FPW1038 {ECO:0000313|EMBL:SPM45301.1};
RA Keele B.F.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000244889}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Batty M. E., Batty M E.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Might be efficient in the degradation of transiently
CC denatured and unfolded proteins which accumulate in the periplasm
CC following stress conditions. {ECO:0000256|ARBA:ARBA00002610}.
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DR EMBL; HM156052; ADO30456.1; -; Genomic_DNA.
DR EMBL; OOHR01000012; SPM45301.1; -; Genomic_DNA.
DR AlphaFoldDB; F4YYF9; -.
DR MEROPS; S01.480; -.
DR Proteomes; UP000244889; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 2.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.40.10.120; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR22939:SF130; PERIPLASMIC SERINE ENDOPROTEASE DEGP-LIKE; 1.
DR PANTHER; PTHR22939; SERINE PROTEASE FAMILY S1C HTRA-RELATED; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:ADO30456.1}.
FT DOMAIN 269..337
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
FT DOMAIN 365..455
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
SQ SEQUENCE 467 AA; 50906 MW; 25871C041ACE3BD7 CRC64;
MKKAFYLHLI VFALQGISNV HSKSLLNQKA VLPQQKSDMH INVNSLSDIV EPLISTVVSI
YAVDTNIGIS LNNKVSKYQQ EVFLGSGVII DSSGYIVTNE NVIAGAENIK VKLHDGSELI
AELVGSDNKI NIALLKINSS AALSYATFGD SNQSRVGDQV IAIGSPFGLR GTVTNGIISS
KGRDMGNGIV TDFIQTNAAV HMGSFGGPMF NLEGKIIGIN SIHVSYSGIS FAIPSNTVFE
AVECLKKGEK IRRGMLNVML NELTPELNEN LGLKKDQNGV LITEVIKEGS AAQCGIVPGD
VITKFHDKEI KTGRDLQVAV SSTMLNSERE VELLRNGKSM TLKCKIIANN KGEDSEQQSN
DQSLVVNGVK FVDLTPDLVK KYNITSANNN GLFVLEVSPN SSWGRYGLKM GLRPRDIILS
VKRDDNKKDI SVKTLREIVT NIKHNEIFFT VQRGDRMLYI ALPNINK
//
