ID F4ZTQ3_9NEOB Unreviewed; 192 AA.
AC F4ZTQ3;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE Flags: Fragment;
GN Name=NT3 {ECO:0000313|EMBL:AEB39033.1};
OS Excidobates captivus (Rio Santiago poison frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Dendrobatidae; Dendrobatinae;
OC Excidobates.
OX NCBI_TaxID=467706 {ECO:0000313|EMBL:AEB39033.1};
RN [1] {ECO:0000313|EMBL:AEB39033.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=36A {ECO:0000313|EMBL:AEB39033.1};
RX PubMed=21444790; DOI=10.1073/pnas.1010952108;
RA Santos J.C., Cannatella D.C.;
RT "Phenotypic integration emerges from aposematism and scale in poison
RT frogs.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:6175-6180(2011).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
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DR EMBL; HQ290799; AEB39033.1; -; Genomic_DNA.
DR AlphaFoldDB; F4ZTQ3; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 128..192
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEB39033.1"
FT NON_TER 192
FT /evidence="ECO:0000313|EMBL:AEB39033.1"
SQ SEQUENCE 192 AA; 21917 MW; 36CBAC64B2512851 CRC64;
TTMDKRNLPE SSMNSLFIKL MQADLLKNKI PNQVVNVKEV KQQSTIPKAE ILDVDMVDSG
KSDFQPVISI EAELFKQQKQ KRYNSPRVLL SDSLPLEPPP LYLMDDFIGH STSSNRTSRR
KRFAEHKSHR GEYSVCDSES LWITNKSNAI DIKGHQVTVL GEIKTGNSPI KQYFYETRCK
DARPFKNGCR GI
//