GenomeNet

Database: UniProt
Entry: F4ZTQ3_9NEOB
LinkDB: F4ZTQ3_9NEOB
Original site: F4ZTQ3_9NEOB 
ID   F4ZTQ3_9NEOB            Unreviewed;       192 AA.
AC   F4ZTQ3;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE            Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE   Flags: Fragment;
GN   Name=NT3 {ECO:0000313|EMBL:AEB39033.1};
OS   Excidobates captivus (Rio Santiago poison frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Dendrobatidae; Dendrobatinae;
OC   Excidobates.
OX   NCBI_TaxID=467706 {ECO:0000313|EMBL:AEB39033.1};
RN   [1] {ECO:0000313|EMBL:AEB39033.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=36A {ECO:0000313|EMBL:AEB39033.1};
RX   PubMed=21444790; DOI=10.1073/pnas.1010952108;
RA   Santos J.C., Cannatella D.C.;
RT   "Phenotypic integration emerges from aposematism and scale in poison
RT   frogs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:6175-6180(2011).
CC   -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC       sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC       ECO:0000256|RuleBase:RU365037}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU365037}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HQ290799; AEB39033.1; -; Genomic_DNA.
DR   AlphaFoldDB; F4ZTQ3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR045815; NTF3_N.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR   Pfam; PF00243; NGF; 1.
DR   Pfam; PF19338; NTF3_N; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01914; NEUROTROPHN3.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW   Growth factor {ECO:0000256|RuleBase:RU365037};
KW   Secreted {ECO:0000256|RuleBase:RU365037};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          128..192
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEB39033.1"
FT   NON_TER         192
FT                   /evidence="ECO:0000313|EMBL:AEB39033.1"
SQ   SEQUENCE   192 AA;  21917 MW;  36CBAC64B2512851 CRC64;
     TTMDKRNLPE SSMNSLFIKL MQADLLKNKI PNQVVNVKEV KQQSTIPKAE ILDVDMVDSG
     KSDFQPVISI EAELFKQQKQ KRYNSPRVLL SDSLPLEPPP LYLMDDFIGH STSSNRTSRR
     KRFAEHKSHR GEYSVCDSES LWITNKSNAI DIKGHQVTVL GEIKTGNSPI KQYFYETRCK
     DARPFKNGCR GI
//
DBGET integrated database retrieval system