ID F4ZUI0_9NEOB Unreviewed; 192 AA.
AC F4ZUI0;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Bone morphogenetic protein 2 {ECO:0000313|EMBL:AEB39191.1};
DE Flags: Fragment;
GN Name=BMP2 {ECO:0000313|EMBL:AEB39191.1};
OS Silverstoneia flotator (rainforest rocket frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Dendrobatidae; Colostethinae;
OC Silverstoneia.
OX NCBI_TaxID=384859 {ECO:0000313|EMBL:AEB39191.1};
RN [1] {ECO:0000313|EMBL:AEB39191.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=14A {ECO:0000313|EMBL:AEB39191.1};
RX PubMed=21444790; DOI=10.1073/pnas.1010952108;
RA Santos J.C., Cannatella D.C.;
RT "Phenotypic integration emerges from aposematism and scale in poison
RT frogs.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:6175-6180(2011).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; HQ291020; AEB39191.1; -; Genomic_DNA.
DR AlphaFoldDB; F4ZUI0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF143; BONE MORPHOGENETIC PROTEIN 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 83..192
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 76..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..97
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEB39191.1"
FT NON_TER 192
FT /evidence="ECO:0000313|EMBL:AEB39191.1"
SQ SEQUENCE 192 AA; 22446 MW; CEC8382FDCB73C34 CRC64;
VHHNVSRWES FDVTPAIIRW IAHRQPNHGF VVEVTPLDYE KNVTKRHVRI SRSLLPDKKR
WSQIRPLLVT YGHDGKGHPL HKREKRQARH RQRKRLKSSC RRHPLYVDFS DVGWNDWIVA
PPGYHAFYCH GECPFPLADH FNSTNHAIVQ TLVNSVNSNI PKACCVPTEL SAISMLYLDE
NEKVVLKNYQ DM
//