ID F5C122_HBV Unreviewed; 736 AA.
AC F5C122;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:AEA48521.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AEA48521.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AEA48521.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BIL2001F12 {ECO:0000313|EMBL:AEA48521.1};
RA Fallot G.;
RT "Recombination of Hepatitis B virus DNA during antiviral therapies.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; JF439895; AEA48521.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 2.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 325..568
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 226..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 736
FT /evidence="ECO:0000313|EMBL:AEA48521.1"
SQ SEQUENCE 736 AA; 82809 MW; D89857EC42D9FF42 CRC64;
MPLSYQHFRK LLLLDDGTEA GPLEEELPRL ADADLNRRVA EDLNLGNLNV SIPWTHKVGN
FTGLYSSTVP IFNPEWQTPS FPKIHLQEDI INRCQQFVGP LTVNEKRRLK LIMPARFYPT
HTKYLPLDKG IKPYYPDQVV NHYFKTRHYL HTLWKAGILY KRETTRSASF CGSPYSWEQE
LQHGRLVIKT SQRHGDESFC SQPSGILSRS SVGPCIRSQL KQSRLGLQPH QGPLASSQPG
RSGSIRARAH PSTRRYFGVE PSGSGHIDHS VNNSSSCLHQ SAQSQGSVVS CWWLQFRNSK
PCSEYCLSHL VNLREDWGPC DEHGEHHIRI PRTPARVTGG VFLVDKNPHN TAESRLVVDF
SQFSRGITRV SWPKFAVPNL QSLTNLLSSN LSWLSLDVSA AFYHIPLHPA AMPHLLIGSS
GLSRYVARLS SNAMINNNQH GTMQNLHDSC SRQLYVSLML LYKTYGWKLH LYSHPIVLGF
RKIPMGVGLS PFLMAQFTSA ICSVVRRAFP HCLAFSYVDD IVLGAKTVQH RESLFTAVTN
FLLSLGIHLN PNKTKRWGYS LNFMGYIIGS WGTLPQDHIV QKIKRCFRKL PVNRPIDWKV
CQRIVGLLGF AAPFTQCGYP ALMPLYACIQ AKQAFTFSPT YKAFLSKQYM NLYPVARQRP
GLCQVFADAT PTGWGLAIGH QRMRGTFVAP LPIHTAELLA ACFARSRSGA KLIGTDNSVV
LSRKYTSFPW LLGCAA
//
