ID F5C153_HBV Unreviewed; 770 AA.
AC F5C153;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:AEA48552.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AEA48552.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AEA48552.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=LAMB00B4 {ECO:0000313|EMBL:AEA48552.1};
RA Fallot G.;
RT "Recombination of Hepatitis B virus DNA during antiviral therapies.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; JF439926; AEA48552.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR HAMAP; MF_04073; HBV_DPOL; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR037531; HBV_DPOL.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 359..602
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 226..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 770
FT /evidence="ECO:0000313|EMBL:AEA48552.1"
SQ SEQUENCE 770 AA; 86262 MW; 65240E637E681D6B CRC64;
MSLSYQHFRN VLLLDDGTEA GPLEEELPRL ADADLNRRVA EDLNLGDLNV SIPWTHKVGN
FTGLYSSTVP IFNPEWQTPS FPKIHLQEDI IDRCQQFVGP LTVNEKRRLK LIMPARFYPT
HTKYLPLDKG IKPYYPDQGV NHYFQTRHYL HTLWKAGVLY KRETTRSASF CGSPYSWEQE
LPHGRLVIQT SQRHGDESFC SQPSGILSRS SVGPCIRSQL KQSRLGLQPH QGPLASSQPG
RSGSIRARAH PSTRRYFGVE PSGSGHIDHS VNNSSSCLHQ SAIRKAAHSH LSTSKRQSSS
GHAVEFHCLP PSSAGSQSQG SVFSCWWLQF RNSKPCSEYC LSHLVNLRED WGPCDEHGEH
HIRIPRTPAR VTGGVFLVDK NPHNTAESRL VVDFSQFSRG STRVSWPKFA VPNLQSLTNL
LSSNLSWLSL DVSAAFYHIP LHPAAMPHLL IGSSGLSRYV ARLSSNSRIN NNQYGTMQNL
HDSCSRQLYV SLMLLYKTYG RKLHLYSHPI VLGFRKIPMG VGLSPFLLTQ FTSAICSVVR
RAFPHCLAFS YMDDVVLGAK SVQHREALYT AVTNFLLSLG IHLNPNKTKR WGYSLNFMGY
IIGSWGTLPQ DHIVHKIKHC FRKLPVNRPI DWKVCQRIVG LLGFAAPFTQ CGYPALMPLY
ACIQAKQAFT FSPTYKAFLS KQYMNLYPVA RQRPGLCQVF ADATPTGWGL AIGHQRMRGT
FVAPLPIHAA ELLAACFARS RSGAKLIGTD NSVVLSRKYT SFPWLLGCAA
//