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Database: UniProt
Entry: F5C153_HBV
LinkDB: F5C153_HBV
Original site: F5C153_HBV 
ID   F5C153_HBV              Unreviewed;       770 AA.
AC   F5C153;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=P {ECO:0000313|EMBL:AEA48552.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AEA48552.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AEA48552.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LAMB00B4 {ECO:0000313|EMBL:AEA48552.1};
RA   Fallot G.;
RT   "Recombination of Hepatitis B virus DNA during antiviral therapies.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
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DR   EMBL; JF439926; AEA48552.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   HAMAP; MF_04073; HBV_DPOL; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR037531; HBV_DPOL.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Inhibition of host innate immune response by virus
KW   {ECO:0000256|ARBA:ARBA00022632};
KW   Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT   DOMAIN          359..602
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          226..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..243
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         770
FT                   /evidence="ECO:0000313|EMBL:AEA48552.1"
SQ   SEQUENCE   770 AA;  86262 MW;  65240E637E681D6B CRC64;
     MSLSYQHFRN VLLLDDGTEA GPLEEELPRL ADADLNRRVA EDLNLGDLNV SIPWTHKVGN
     FTGLYSSTVP IFNPEWQTPS FPKIHLQEDI IDRCQQFVGP LTVNEKRRLK LIMPARFYPT
     HTKYLPLDKG IKPYYPDQGV NHYFQTRHYL HTLWKAGVLY KRETTRSASF CGSPYSWEQE
     LPHGRLVIQT SQRHGDESFC SQPSGILSRS SVGPCIRSQL KQSRLGLQPH QGPLASSQPG
     RSGSIRARAH PSTRRYFGVE PSGSGHIDHS VNNSSSCLHQ SAIRKAAHSH LSTSKRQSSS
     GHAVEFHCLP PSSAGSQSQG SVFSCWWLQF RNSKPCSEYC LSHLVNLRED WGPCDEHGEH
     HIRIPRTPAR VTGGVFLVDK NPHNTAESRL VVDFSQFSRG STRVSWPKFA VPNLQSLTNL
     LSSNLSWLSL DVSAAFYHIP LHPAAMPHLL IGSSGLSRYV ARLSSNSRIN NNQYGTMQNL
     HDSCSRQLYV SLMLLYKTYG RKLHLYSHPI VLGFRKIPMG VGLSPFLLTQ FTSAICSVVR
     RAFPHCLAFS YMDDVVLGAK SVQHREALYT AVTNFLLSLG IHLNPNKTKR WGYSLNFMGY
     IIGSWGTLPQ DHIVHKIKHC FRKLPVNRPI DWKVCQRIVG LLGFAAPFTQ CGYPALMPLY
     ACIQAKQAFT FSPTYKAFLS KQYMNLYPVA RQRPGLCQVF ADATPTGWGL AIGHQRMRGT
     FVAPLPIHAA ELLAACFARS RSGAKLIGTD NSVVLSRKYT SFPWLLGCAA
//
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