ID   F5CNJ5_SALET            Unreviewed;       268 AA.
AC   F5CNJ5;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252};
DE            EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126};
DE   Flags: Fragment;
GN   Name=aadA1 {ECO:0000313|EMBL:AEB52076.1};
OS   Salmonella enterica subsp. enterica serovar Oslo.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=1005394 {ECO:0000313|EMBL:AEB52076.1};
RN   [1] {ECO:0000313|EMBL:AEB52076.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=244 {ECO:0000313|EMBL:AEB52076.1};
RA   Karani M.N., Shashidhar R., Kakatkar A.S., Bandekar J.R.;
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC         Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC         Evidence={ECO:0000256|ARBA:ARBA00001672};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC         Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC         Evidence={ECO:0000256|ARBA:ARBA00035070};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JF747229; AEB52076.1; -; Genomic_DNA.
DR   AlphaFoldDB; F5CNJ5; -.
DR   GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd05403; NT_KNTase_like; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR024172; AadA/Aad9.
DR   InterPro; IPR025184; AadA_C.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   Pfam; PF13427; AadA_C; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE   4: Predicted;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Transferase {ECO:0000313|EMBL:AEB52076.1}.
FT   DOMAIN          63..110
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          187..268
FT                   /note="Adenylyltransferase AadA C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13427"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEB52076.1"
FT   NON_TER         268
FT                   /evidence="ECO:0000313|EMBL:AEB52076.1"
SQ   SEQUENCE   268 AA;  29826 MW;  DD10EB1EE95740C1 CRC64;
     ASKQQARYAV GRCLMLWSSN DVTQQGSRPK TKLNIMREAM IAEVSTQLSE VVGVIERHLE
     PTLLAVHLYG SAVDGGLKPH SDIDLLVTVT VRLDETTRRA LINDLLETSA SPGESEILRA
     VEVTIVVHDD IIPWRYPAKR ELQFGEWQRN DILAGIFEPA TIDIDLAILL TKAREHSVAL
     VGPAAEELFD PVPEQDLFEA LNETLTLWNS PPDWAGDERN VVLTLSRIWY SAVTGKIAPK
     DVAADWAMER LPAQYQPVIL EARQAYLG
//