ID F5H6X6_HUMAN Unreviewed; 847 AA.
AC F5H6X6;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE SubName: Full=Glucosidase II alpha subunit {ECO:0000313|Ensembl:ENSP00000442962.1};
GN Name=GANAB {ECO:0000313|Ensembl:ENSP00000442962.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000442962.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000442962.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [4] {ECO:0007829|PubMed:25944712}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [5] {ECO:0000313|Ensembl:ENSP00000442962.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
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DR EMBL; AP001458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001265123.1; NM_001278194.1.
DR RefSeq; NP_001316151.1; NM_001329222.1.
DR RefSeq; NP_001316152.1; NM_001329223.1.
DR RefSeq; XP_016872901.1; XM_017017412.1.
DR MassIVE; F5H6X6; -.
DR ProteomicsDB; 27320; -.
DR Antibodypedia; 14863; 229 antibodies from 29 providers.
DR DNASU; 23193; -.
DR Ensembl; ENST00000540933.5; ENSP00000442962.1; ENSG00000089597.18.
DR Ensembl; ENST00000648273.1; ENSP00000497655.1; ENSG00000089597.18.
DR GeneID; 23193; -.
DR UCSC; uc001nuc.5; human.
DR CTD; 23193; -.
DR HGNC; HGNC:4138; GANAB.
DR VEuPathDB; HostDB:ENSG00000089597; -.
DR GeneTree; ENSGT00940000159139; -.
DR OMA; QAGIWYP; -.
DR OrthoDB; 5480935at2759; -.
DR BioGRID-ORCS; 23193; 83 hits in 1166 CRISPR screens.
DR ChiTaRS; GANAB; human.
DR GenomeRNAi; 23193; -.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000089597; Expressed in stromal cell of endometrium and 210 other cell types or tissues.
DR GO; GO:0090599; F:alpha-glucosidase activity; IEA:UniProt.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06603; GH31_GANC_GANAB_alpha; 1.
DR CDD; cd14752; GH31_N; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 2.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR030458; Glyco_hydro_31_AS.
DR InterPro; IPR048395; Glyco_hydro_31_C.
DR InterPro; IPR030459; Glyco_hydro_31_CS.
DR InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR22762:SF162; NEUTRAL ALPHA-GLUCOSIDASE AB; 1.
DR Pfam; PF13802; Gal_mutarotas_2; 1.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 1.
DR Pfam; PF21365; Glyco_hydro_31_3rd; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
DR PROSITE; PS00129; GLYCOSYL_HYDROL_F31_1; 1.
DR PROSITE; PS00707; GLYCOSYL_HYDROL_F31_2; 1.
PE 1: Evidence at protein level;
KW Glycosidase {ECO:0000256|RuleBase:RU361185};
KW Hydrolase {ECO:0000256|RuleBase:RU361185};
KW Proteomics identification {ECO:0007829|EPD:F5H6X6,
KW ECO:0007829|MaxQB:F5H6X6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 9..227
FT /note="Glycoside hydrolase family 31 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13802"
FT DOMAIN 290..617
FT /note="Glycoside hydrolase family 31 TIM barrel"
FT /evidence="ECO:0000259|Pfam:PF01055"
FT DOMAIN 625..713
FT /note="Glycosyl hydrolase family 31 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21365"
FT REGION 84..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 96216 MW; 68FE62252A5B076E CRC64;
MTRFRIDELE PRRPRYRVPD VLVADPPIAR LSVSGRDENS VELTMAEGPY KIILTARPFR
LDLLEDRSLL LSVNARGLLE FEHQRAPRVS QGSKDPAEGD GAQPEETPRD GDKPEETQGK
AEKDEPGAWE ETFKTHSDSK PYGPMSVGLD FSLPGMEHVY GIPEHADNLR LKVTEGGEPY
RLYNLDVFQY ELYNPMALYG SVPVLLAHNP HRDLGIFWLN AAETWVDISS NTAGKTLFGK
MMDYLQGSGE TPQTDVRWMS ETGIIDVFLL LGPSISDVFR QYASLTGTQA LPPLFSLGYH
QSRWNYRDEA DVLEVDQGFD DHNLPCDVIW LDIEHADGKR YFTWDPSRFP QPRTMLERLA
SKRRKLVAIV DPHIKVDSGY RVHEELRNLG LYVKTRDGSD YEGWCWPGSA GYPDFTNPTM
RAWWANMFSY DNYEGSAPNL FVWNDMNEPS VFNGPEVTML KDAQHYGGWE HRDVHNIYGL
YVHMATADGL RQRSGGMERP FVLARAFFAG SQRFGAVWTG DNTAEWDHLK ISIPMCLSLG
LVGLSFCGAD VGGFFKNPEP ELLVRWYQMG AYQPFFRAHA HLDTGRREPW LLPSQHNDII
RDALGQRYSL LPFWYTLLYQ AHREGIPVMR PLWVQYPQDV TTFNIDDQYL LGDALLVHPV
SDSGAHGVQV YLPGQGEVWY DIQSYQKHHG PQTLYLPVTL SSIPVFQRGG TIVPRWMRVR
RSSECMKDDP ITLFVALSPQ GTAQGELFLD DGHTFNYQTR QEFLLRRFSF SGNTLVSSSA
DPEGHFETPI WIERVVIIGA GKPAAVVLQT KGSPESRLSF QHDPETSVLV LRKPGINVAS
DWSIHLR
//