ID F5HIY5_ANOGA Unreviewed; 1648 AA.
AC F5HIY5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=AGAP005279-PB {ECO:0000313|EMBL:EGK96246.1};
GN ORFNames=AgaP_AGAP005279 {ECO:0000313|EMBL:EGK96246.1};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EGK96246.1};
RN [1] {ECO:0000313|EMBL:EGK96246.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EGK96246.1};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EGK96246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EGK96246.1};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EGK96246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EGK96246.1};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EGK96246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EGK96246.1};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EGK96246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EGK96246.1};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGK96246.1}.
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DR EMBL; AAAB01008810; EGK96246.1; -; Genomic_DNA.
DR RefSeq; XP_003435721.1; XM_003435673.1.
DR STRING; 7165.F5HIY5; -.
DR PaxDb; 7165-AGAP005279-PB; -.
DR GeneID; 1270384; -.
DR KEGG; aga:AgaP_AGAP005279; -.
DR VEuPathDB; VectorBase:AGAP005279; -.
DR eggNOG; KOG2200; Eukaryota.
DR HOGENOM; CLU_003214_0_0_1; -.
DR OMA; CASTLEI; -.
DR OrthoDB; 2883046at2759; -.
DR PhylomeDB; F5HIY5; -.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04375; RhoGAP_DLC1; 1.
DR CDD; cd09538; SAM_DLC1_2-like; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659:SF7; CROSSVEINLESS C, ISOFORM C; 1.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
FT DOMAIN 1202..1409
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1437..1618
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 1..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1076
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1077..1110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1648 AA; 180675 MW; 5A76265885DE48CE CRC64;
MTSLSSDSRC PGSSTSNSNS NSSNGGDVAN NNNHLPKDAS TSRADIVVCR TKMRDQGAVG
NGHVATVADG RGGAKQGGSM CHPEQSRTIH PRTQMESQSQ GDRTATAHPS SSAASPSTID
SCDPARYKGS SQPAAASTAR HHRSSSLGDR DMTDSASPGA STTTVGSTVQ KPEDPYAELE
RILEKVQAEI SEMFEQTLLE GNAAPAVASS NDTVRGTGSD KKRKNDLKAN RDEATGYGRL
VKAGPHLQQH HHHQQQPHQQ NASHHVKYAT IPHANVTQQN NSASAGAISY GRTNQSLAID
GYAKRTRNAQ DPRYRSHDRM EMVSSSTTVP AAASTLPKQS VRSQSAGENM SSSGYSSYGR
YTERSDSLSD DMSLLDVGAP SCDDSLEGAG DDTTSDERET IVSGGVRKRL QQKDPSVQAQ
RGAGAIAPSK DFGGYYCNSI EQQLGANDRG LKTSTNSLPS VAGGHRNLAL HLKFKSHQSA
IDAKRKQFFL TLDQEPFQPL KSNMADLPSP SSTSLHSGHN HLIAEELGSK SSSAPVLLKD
EENVLTVARA NLRYSRSQSD RHLAEIEAIE ACRWLRAAGF PQYAQMYEDH QFPIIVEDVA
KDHPFLEPDP LQSLFRRLHT LNRCANMHLD AHQHTPKPSQ RDDSDDDSCA LSEAWTFQHN
SRRWSRVDDA IGLVSVINNK QQQQQQRNSH KDGKGSGSDH AAGSQRRHHN NNNTLLRAED
HEKLWLESGG KITIGVPSDT DSQDDCGTNG SGVHLRRTGS ERLKDGAKAI LRRVESIKSR
RRKKQNRDGL IILAPPAAHS SAHLSPHHRP AGGDGTDGYG GSGFDIMSYS NPTSPRPSAE
LLAFDDALDA AGNRRKDLFG NDLLGRRNLL LSPNVSTPAP AWSPLHGADG KRYTDRSSPG
GTLPFRQQVQ LQQESRSGDD SSSICSEDSG GGGGGPDLNL LTGRSDKMAS RKYPRAKKAL
RSKVISSTVA DDQSGSGALS DSECHAKQRR SKIKIELDCD LPGMNDGVST TTGDGKGAGR
GVGNNTLTAP DAAPSKLHRG GSLNLGKASK RYRDAFSNRS VRHSSKTADD GGEGRSSSKR
STVARWHSFQ QPKVSPIDLQ QQQQQQQPDQ LGSKDDRKHA LQPIGRGLDG SATSGAGLRM
SEMSCGQLLV VRKLGLANLT GYMERYCPTH RSGWNWDLPK FIKRIKTPDY KDRKVFGMPL
VLNLQKYGST VPHTIRLAFG WLEKNALDQV GLFRKPGVKS RIAKLKSVIE ASNDVGWRSE
MFDEYHAYDV ADLVKQYFRE LPDPLLTAKL SETFIAIFQY LPNEVRAEAV QSAILLLPDE
HREVLHLLLT FLEKVVQNSS LNQMTANNLS VCFAPSLFYL LSGNRYTAAS PRRKKTGAGS
GTPDEKELSE AKASHECLAY MVEHFQTLWT ISSDQMRRCN FNYMDESKPV PLASLGTEMH
VQNWRGYLSE SINECLREGR ERPRGWVSLS SSDPSVTAFF KKVGDGHPLR LWKCVTEVEA
PPMEVIQHIV NERPLWDAYL LKWRTIEQLD QDTDVFQYAC GQPVTEYCVV RQWKNDLPRG
ACVIVEVSIS HENATTLLGG VNGVVLASRY LIEPCGSGKC KLMHLSRVDM KGRTPDWYNK
NYGHICQQYL SKIKKFFEHC TEGPETKV
//
