ID F5HK16_ANOGA Unreviewed; 818 AA.
AC F5HK16;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=AGAP003428-PB {ECO:0000313|EMBL:EGK96627.1};
GN Name=1272801 {ECO:0000313|EnsemblMetazoa:AGAP003428-PB};
GN ORFNames=AgaP_AGAP003428 {ECO:0000313|EMBL:EGK96627.1};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EGK96627.1};
RN [1] {ECO:0000313|EMBL:EGK96627.1, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EGK96627.1,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EGK96627.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EGK96627.1};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EGK96627.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EGK96627.1};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EGK96627.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EGK96627.1};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EGK96627.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EGK96627.1};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP003428-PB}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP003428-PB};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
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DR EMBL; AAAB01008851; EGK96627.1; -; Genomic_DNA.
DR RefSeq; XP_003436477.1; XM_003436429.1.
DR AlphaFoldDB; F5HK16; -.
DR STRING; 7165.F5HK16; -.
DR PaxDb; 7165-AGAP003428-PB; -.
DR EnsemblMetazoa; AGAP003428-RB; AGAP003428-PB; AGAP003428.
DR GeneID; 1272801; -.
DR KEGG; aga:AgaP_AGAP003428; -.
DR VEuPathDB; VectorBase:AGAP003428; -.
DR eggNOG; KOG1987; Eukaryota.
DR HOGENOM; CLU_345538_0_0_1; -.
DR InParanoid; F5HK16; -.
DR OrthoDB; 5473088at2759; -.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0030162; P:regulation of proteolysis; IBA:GO_Central.
DR CDD; cd18345; BTB_POZ_roadkill-like; 1.
DR CDD; cd03774; MATH_SPOP; 1.
DR Gene3D; 6.10.250.3030; -; 1.
DR Gene3D; 6.20.250.50; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR008974; TRAF-like.
DR PANTHER; PTHR24413:SF213; PROTEIN ROADKILL; 1.
DR PANTHER; PTHR24413; SPECKLE-TYPE POZ PROTEIN; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00917; MATH; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50144; MATH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 75..205
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 244..306
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 450..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..735
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 818 AA; 86319 MW; 6FA6DD72F6BBA231 CRC64;
MCLPFYFMPY SLFSVFFSRL PVVSDCPAGQ TARVTSNLHS SSSTMANSRV PSPPLPEVNT
PVAENWCYTQ VKVVKFSYMW TINNFSFCRE EMGEVLKSST FSAGANDKLK WCLRVNPKGL
DEESKDYLSL YLLLVSCNKS EVRAKFKFSI LNAKREETKA MESQRAYRFV QGKDWGFKKF
IRRDFLLDEA NGLLPEDKLT IFCEVSVVAD SVNISGQSNI IQFKVPECKL SEDLGTLFDN
EKFSDVTLAV GGREFQVHKA ILAARSPVFA AMFEHEMEER KQNRVAITDV DHEVLKEMLR
FIYTGKAPNL DKMADDLLAA ADKYALDKLK VMCEEALCVN LSVETAAETL ILADLHSADQ
LKAQTIDFIN THATDVVETV GWKNMVATHP HLLNEAYRAL ATQQIPPIGP PRKRQLLPLS
LAASPSPALV QSSTVAASNS GSASLLINHL TSSSKPTPSS PPGAAAPASP SSSPSSSSVG
SGGRVEAAKP STTVRTEETI GGKRQAPLVL VASATTPRKT KLSHSSGHSS ALIGGRGGGA
VADGDPACPK VALASPIVNV VVNDIAAGLA NAVAAAVADA VTVATIGRNL IMATTAAAAP
PSAGNRHHHH NARTNATTTN TNGGGTALNS YSQLRQQLEM GSSAAVVGGG VGKGVAGPHQ
HHHRHHHQAS SQQQQQQHSH LKQFLSAGAG AAGGGGVGGV MVATAGGAGN QHPGGAAQQH
HHHHHHHHHV HSQSRRHAAG GSSSGAVAGG STASSSGGSA AATTGATSQP EVVVTIHDSS
NGSNGSSSSG SGNGRNNNRS TNAIVDANSN HHHHHHRW
//
