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Database: UniProt
Entry: F5HLG0_ANOGA
LinkDB: F5HLG0_ANOGA
Original site: F5HLG0_ANOGA 
ID   F5HLG0_ANOGA            Unreviewed;      1154 AA.
AC   F5HLG0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 51.
DE   SubName: Full=AGAP003709-PF {ECO:0000313|EMBL:EGK97123.1};
DE   SubName: Full=Potassium large conductance calcium-activated channel subfamily M alpha member {ECO:0000313|VectorBase:AGAP003709-PF};
GN   Name=1274388 {ECO:0000313|VectorBase:AGAP003709-PF};
GN   ORFNames=AgaP_AGAP003709 {ECO:0000313|EMBL:EGK97123.1};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|VectorBase:AGAP003709-PF}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP003709-PF};
RX   PubMed=9087549; DOI=10.1111/j.1365-2583.1993.tb00131.x;
RA   Beard C.B., Hamm D.M., Collins F.H.;
RT   "The mitochondrial genome of the mosquito Anopheles gambiae: DNA
RT   sequence, genome organization, and comparisons with mitochondrial
RT   sequences of other insects.";
RL   Insect Mol. Biol. 2:103-124(1993).
RN   [2] {ECO:0000313|EMBL:EGK97123.1, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EGK97123.1,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R.,
RA   Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A., Liang Y., Lin J.J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A., Wang J.,
RA   Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [3] {ECO:0000313|EMBL:EGK97123.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EGK97123.1};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:EGK97123.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EGK97123.1};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [5] {ECO:0000313|EMBL:EGK97123.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EGK97123.1};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [6] {ECO:0000313|EMBL:EGK97123.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EGK97123.1};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|VectorBase:AGAP003709-PF}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP003709-PF};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
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DR   EMBL; AAAB01008888; EGK97123.1; -; Genomic_DNA.
DR   RefSeq; XP_003436579.1; XM_003436531.1.
DR   PaxDb; F5HLG0; -.
DR   EnsemblMetazoa; AGAP003709-RF; AGAP003709-PF; AGAP003709.
DR   GeneID; 1274388; -.
DR   VectorBase; AGAP003709-RF; AGAP003709-PF; AGAP003709.
DR   eggNOG; KOG1420; Eukaryota.
DR   eggNOG; ENOG410YUX1; LUCA.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR10027:SF37; PTHR10027:SF37; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     29     53       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    109    127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    148    166       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    172    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    231    252       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    267    286       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    298    318       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    320       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1154 AA;  129073 MW;  953D95D2C93B8B68 CRC64;
     MSGCDEEQSV LTTELPPTDL DDCLRVRKWW CFLLSSIFTF LAGLLAVLLW RAFAFLCCRK
     EPELAPNDPK QKEQKASRQG KQDFEGTFMT EAKDWAGELI SGQTTTGRIL VVLVFILSIA
     SLIIYFIDAS NEEVERCQKW SNNITQQIDL AFNIFFMVYF FIRFIAASDK LWFMLEMYSF
     VDYFTIPPSF VSIYLDRTWI GLRFLRALRL MTVPDILQYL NILKTSSSIR LAQLVSIFIS
     VWLTAAGIIH LLENSGDPLE FNNPQQLSYW TCVYFLIVTM STVGYGDVYC ETVLGRTFLV
     FFLLVGLAIF ASCIPEIIDL IGTRPKYGGT LKNERGRRHI VVCGHITYES VSHFLKDFLH
     EDREDVDVEV VFLHRKEPDL ELEGLLKRHY TTVEFFQGTM MNAVDLERVK VHEADACLVL
     ANKYCQDPDA EDAANIMRVI SIKNYSDDIR VIIQLMQYHN KAYLLNIPSW DWKQGDDVIC
     LAELKLGFIA QSCLAPGFST MMANLFAMRS FKTSPDMQVW TNDYLRGTGM EMYTETLSPS
     FIGMPFAQAT ELCFTKLKLL LLAIEIKGGE EGNDSKISIN PRGAKILANT QGFFIAQSAD
     EVKRAWFYCK ACHDDIKDET LIKKCKCKNF TLRKTTAILL GCDITRDRED INLSCNIDVY
     RSNGALLLIN RNRRSNVSMT GSNQMLNSTK QVNKVKPNVN RQPPDNLISP STYNRPTSRG
     SGSGAQSQNG VTLQAGIADD QSKDFDFEKT EMKYDSTGMF HWSPAKSLEE CILDRNQAAM
     TVLNGHVVVC LFADPDSPLI GLRNLVMPLR ASNFHYHELK HVVIVGSVEY IRREWKMLQN
     LPKISVLNGS PLSRADLRAV NVNLCDMCCI LSAKVPSNDD PTLADKEAIL ASLNIKAMTF
     DDTIGVLSQR GSEQDNLTPV GSPIVLQRRG SVYGANVPMI TELVNDSNVQ FLDQDDDDDP
     DTELYLTQPF ACGTAFAVSV LDSLMSTTYF NQNALTLIRS LITGGATPEL ELILAEGAGL
     RGGYSTPESL SNRDRCRVGQ ISLYDGPLAQ FGEAGKYGDL FVAALKSYGM LCIGLYRFRD
     TSSSCDASSK RYVITNPPDD FSLLPTDQVF VLMQFDPGLE YKPATVRGPS GGGRNQNSQA
     AGVGGGGSNK DDNS
//
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