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Database: UniProt
Entry: F5HLG5_ANOGA
LinkDB: F5HLG5_ANOGA
Original site: F5HLG5_ANOGA 
ID   F5HLG5_ANOGA            Unreviewed;       838 AA.
AC   F5HLG5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   25-OCT-2017, entry version 43.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=1274390 {ECO:0000313|VectorBase:AGAP003711-PB,
GN   ECO:0000313|VectorBase:AGAP003711-PC};
GN   ORFNames=AgaP_AGAP003711 {ECO:0000313|EMBL:EGK97125.1};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EGK97125.1, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|VectorBase:AGAP003711-PB, ECO:0000313|VectorBase:AGAP003711-PC}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP003711-PB,
RC   ECO:0000313|VectorBase:AGAP003711-PC};
RX   PubMed=9087549; DOI=10.1111/j.1365-2583.1993.tb00131.x;
RA   Beard C.B., Hamm D.M., Collins F.H.;
RT   "The mitochondrial genome of the mosquito Anopheles gambiae: DNA
RT   sequence, genome organization, and comparisons with mitochondrial
RT   sequences of other insects.";
RL   Insect Mol. Biol. 2:103-124(1993).
RN   [2] {ECO:0000313|EMBL:EGK97125.1, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EGK97125.1,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R.,
RA   Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A., Liang Y., Lin J.J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A., Wang J.,
RA   Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [3] {ECO:0000313|EMBL:EGK97125.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EGK97125.1};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:EGK97125.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EGK97125.1};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [5] {ECO:0000313|EMBL:EGK97125.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EGK97125.1};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [6] {ECO:0000313|EMBL:EGK97125.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EGK97125.1};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|VectorBase:AGAP003711-PB, ECO:0000313|VectorBase:AGAP003711-PC}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP003711-PB,
RC   ECO:0000313|VectorBase:AGAP003711-PC};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AAAB01008888; EGK97124.1; -; Genomic_DNA.
DR   EMBL; AAAB01008888; EGK97125.1; -; Genomic_DNA.
DR   RefSeq; XP_003436583.1; XM_003436535.1.
DR   RefSeq; XP_003436584.1; XM_003436536.1.
DR   EnsemblMetazoa; AGAP003711-RB; AGAP003711-PB; AGAP003711.
DR   EnsemblMetazoa; AGAP003711-RC; AGAP003711-PC; AGAP003711.
DR   GeneID; 1274390; -.
DR   VectorBase; AGAP003711-RB; AGAP003711-PB; AGAP003711.
DR   VectorBase; AGAP003711-RC; AGAP003711-PC; AGAP003711.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    402    431       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    451    470       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    540    558       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    573    593       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    645    664       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    766    791       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   838 AA;  95368 MW;  EDF12E00F594904E CRC64;
     MGSLFRSEEM SLCQLFLQSE AAYACVSELG ELGLVQFRDL NPDVNAFQRK FVNEVRRCDE
     MERKLRYLEK EIKKDGIPML DTGESPEAPQ PREMIDLEAT FEKLENELRE VNQNAEALKR
     NYLELTELKH ILRKTQVFFD EMADSHREEE QVNLLGEEGI RAGGAGAQGQ NLKLGFVAGV
     ILRERLPAFE RMLWRACRGN VFLRQAMIED PLEDPSNGDK VYKSVFIIFF QGDQLKTRVK
     KICEGFRATL YPCPEAPTDR REMAMGVMTR IEDLHTVLGQ TQDHRHRVLV AAAKNLKNWF
     VKVRKIKAIY HTLNLFNLDV TQKCLIAECW VPLLDFETIQ IALRRGTERS GSSVPPILNR
     METFEDPPTY NRTNKFTHAF QALINAYGVA SYREMNPAPY TIITFPFLFA VMFGDLGHGT
     IMALFGLWMV LKEKPLAAKK SDNEIWNIFF GGRYIIFLMG VFSMYTGFVY NDIFSKSLNV
     FGSAWSTNYN TSTVMSNKAL QLNPKGMDYA QTPYPFGLDP VWQVAPLNKI IFQNAYKMKI
     SIIFGVIHML FGVFVGLFNH RYFKNKMAIY CEFIPQVIFL VFLFFYMTLL MFIKWVKYSA
     SATDVVYSEG CAPSILITFI NMVLFKAPDE HTGDCSPYMF AGQSGLQKFL VVVALLCVPW
     MLLAKPILIM RGRKEAAVSV FIETLDDSGT QAGQQPAQQQ GGGHGHDNEE MSEIFIHQGI
     HTIEYVLGSV SHTASYLRLW ALSLAHAQLA EVLWNMVLQN GLKQDGWIGG IALWAVFAFW
     AVLTVGILVL MEGLSAFLHT LRLHWVEFQS KFYAGLGYAF QPFSFEVILE SSSSSSED
//
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