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Database: UniProt
Entry: F5L538_9BACI
LinkDB: F5L538_9BACI
Original site: F5L538_9BACI 
ID   F5L538_9BACI            Unreviewed;       454 AA.
AC   F5L538;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   25-OCT-2017, entry version 43.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=CathTA2_0901 {ECO:0000313|EMBL:EGL83540.1};
OS   Caldalkalibacillus thermarum TA2.A1.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae;
OC   Caldalkalibacillus.
OX   NCBI_TaxID=986075 {ECO:0000313|EMBL:EGL83540.1, ECO:0000313|Proteomes:UP000010716};
RN   [1] {ECO:0000313|EMBL:EGL83540.1, ECO:0000313|Proteomes:UP000010716}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TA2.A1 {ECO:0000313|EMBL:EGL83540.1,
RC   ECO:0000313|Proteomes:UP000010716};
RX   PubMed=21685297; DOI=10.1128/JB.05035-11;
RA   Kalamorz F., Keis S., McMillan D.G., Olsson K., Stanton J.A.,
RA   Stockwell P., Black M.A., Klingeman D.M., Land M.L., Han C.S.,
RA   Martin S.L., Becher S.A., Peddie C.J., Morgan H.W., Matthies D.,
RA   Preiss L., Meier T., Brown S.D., Cook G.M.;
RT   "Draft genome sequence of the thermoalkaliphilic Caldalkalibacillus
RT   thermarum strain TA2.A1.";
RL   J. Bacteriol. 193:4290-4291(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EGL83540.1}.
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DR   EMBL; AFCE01000098; EGL83540.1; -; Genomic_DNA.
DR   RefSeq; WP_007503521.1; NZ_AFCE01000098.1.
DR   STRING; 986075.CathTA2_0901; -.
DR   EnsemblBacteria; EGL83540; EGL83540; CathTA2_0901.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000010716; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010716};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010716}.
FT   DOMAIN      148    276       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      360    429       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     156    163       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   454 AA;  51718 MW;  1A1806F3DE766E7C CRC64;
     MENVRDLWAR VLQEIKDKVS KPSYETWLES TQAHALENDT LVIVAPNEFI RDWLDNHYRP
     LISETVFDIT GVKLNLKFIL PQHEPIEDVD VSVAFRKTEP KPKVSSAGEE HYHGMLNPKY
     TFDSFVVGAG NRFAHAASLA VAEAPAKAYN PFFIYGGVGL GKTHLMQAIG HYVLENNPEA
     RVVYTTSEKF TNEFINAILD NKTTEFRNKY RNVDVLLVDD IQFLAGKEQT QEEFFHTFNT
     LHEEAKQIVI SSDRPPKEIP TLEDRLRSRF EWGLITDITP PDLETRIAIL RKKAKAENLD
     IPNEVLVYIA DLINTNIREL EGALTRVVAY STMTNQDIST ELAQEALKDI APSNKPHLIT
     IAHIQQVVAD HFGLKVEDLK GKKRTKSIAY PRQVAMYLSR ELTDSSLPKI GQEFGGRDHT
     TVIHAHEKIK KDLQKDTSFQ KIVEHLIKVI KKET
//
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