ID F5RJN0_9FIRM Unreviewed; 631 AA.
AC F5RJN0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900, ECO:0000256|RuleBase:RU361257};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900, ECO:0000256|RuleBase:RU361257};
GN ORFNames=HMPREF9081_0465 {ECO:0000313|EMBL:EGK61681.1};
OS Centipeda periodontii DSM 2778.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Centipeda.
OX NCBI_TaxID=888060 {ECO:0000313|EMBL:EGK61681.1, ECO:0000313|Proteomes:UP000004067};
RN [1] {ECO:0000313|EMBL:EGK61681.1, ECO:0000313|Proteomes:UP000004067}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2778 {ECO:0000313|EMBL:EGK61681.1,
RC ECO:0000313|Proteomes:UP000004067};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279,
CC ECO:0000256|RuleBase:RU361257};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594, ECO:0000256|RuleBase:RU361257}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGK61681.1}.
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DR EMBL; AFHQ01000012; EGK61681.1; -; Genomic_DNA.
DR AlphaFoldDB; F5RJN0; -.
DR STRING; 888060.HMPREF9081_0465; -.
DR eggNOG; COG0338; Bacteria.
DR eggNOG; COG3392; Bacteria.
DR HOGENOM; CLU_439881_0_0_9; -.
DR Proteomes; UP000004067; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.1020.10; Adenine-specific Methyltransferase, Domain 2; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR012186; Ade-mod_methylase_MStsI.
DR InterPro; IPR023095; Ade_MeTrfase_dom_2.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR012327; MeTrfase_D12.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00571; dam; 1.
DR PANTHER; PTHR30481; DNA ADENINE METHYLASE; 1.
DR Pfam; PF02086; MethyltransfD12; 2.
DR PIRSF; PIRSF036638; M_m6A_StsI; 1.
DR PRINTS; PR00505; D12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR PROSITE; PS00092; N6_MTASE; 2.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU361257};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|RuleBase:RU361257};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361257}.
SQ SEQUENCE 631 AA; 71672 MW; 184DB671C3221832 CRC64;
MTVSANMDRT EAYKAKPILK WAGGKTQLLG ELCAKVPPRY GKYIEPFFGG GALFFALAPE
RAVLADSNPE LINMYRAVAA DAEQVIAHLE QYENTSEHFY EVRALDWEQL SPVEAAARTI
FLNKTCFNGL YRVNQKGQFN VPFGRYKNPK ICDRAAILAA TRVLSRAEII CGDYLDVLET
HAAAGDLIFL DPPYLPISAY ADFKRYTKER FYEEDHVRLA EMVARLHERG CYVILTNSNH
PLVHELYARY PIEIIQTKRH ISSNGKSRRG EDVIVTAAPV ARPRIARVEV PLSARVAQYP
PTRFMGSKQK LLHEVWAVAS QFGAETITDL FSGSGIVSYM FKAQGKTVLS NDYMAMSATF
SKAMVENNTV TLSSCTAEEL LLAQKESDHF VARTFQGLYY TDEENDLIDT LRTNIAHLRN
PYERAIAMTA LIRACIKKRP RGIFTYTGHR YDDGRKDLQK TLEEQFLEAV ELVNAAVFDN
GRASRARWGD AMTVRIPSDL VYMDPPYYSP LSDNEYVRRY HFVEGLARNW EGVEIQEHTL
TKKFKSYPTP FSTRLGAAEA FDRLFRKFAK SVLVVSYSSN SLPTQEEMLA LMAKYKEHVE
VIPVDYKYSF GNQATAKTHR NAVQEYLFVG Y
//
