ID F5T6R3_9FIRM Unreviewed; 399 AA.
AC F5T6R3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Oxidoreductase, NAD-binding domain protein {ECO:0000313|EMBL:EGL36868.1};
DE EC=3.2.1.49 {ECO:0000313|EMBL:EGL36868.1};
GN ORFNames=HMPREF9124_2270 {ECO:0000313|EMBL:EGL36868.1};
OS Oribacterium sp. oral taxon 108 str. F0425.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Oribacterium.
OX NCBI_TaxID=904296 {ECO:0000313|EMBL:EGL36868.1, ECO:0000313|Proteomes:UP000003787};
RN [1] {ECO:0000313|EMBL:EGL36868.1, ECO:0000313|Proteomes:UP000003787}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0425 {ECO:0000313|EMBL:EGL36868.1,
RC ECO:0000313|Proteomes:UP000003787};
RA Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Nelson K.E.;
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109
CC subfamily. {ECO:0000256|ARBA:ARBA00009329}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGL36868.1}.
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DR EMBL; AFIH01000001; EGL36868.1; -; Genomic_DNA.
DR RefSeq; WP_009428483.1; NZ_AFIH01000001.1.
DR AlphaFoldDB; F5T6R3; -.
DR STRING; 904296.HMPREF9124_2270; -.
DR eggNOG; COG0673; Bacteria.
DR OrthoDB; 9771072at2; -.
DR Proteomes; UP000003787; Unassembled WGS sequence.
DR GO; GO:0008456; F:alpha-N-acetylgalactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR049303; Glyco_hydro_109_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43818; BCDNA.GH03377; 1.
DR PANTHER; PTHR43818:SF1; GLYCOSYL HYDROLASE FAMILY 109 PROTEIN; 1.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF21252; Glyco_hydro_109_C; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000313|EMBL:EGL36868.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EGL36868.1}.
FT DOMAIN 5..125
FT /note="Gfo/Idh/MocA-like oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01408"
FT DOMAIN 139..303
FT /note="Glycosyl hydrolase 109 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21252"
SQ SEQUENCE 399 AA; 45341 MW; 38660BBACB01987B CRC64;
MGRKINLGVV GLGQRGAELV KNVYSEHPDV EFIALCDVYE DRREDIAKAL EEMGRERPKC
FSDYREMLEM KELDAVLISA SWDTHSEIAI AAMRAGKAVA SEVGGAYSVA ECWRLVDCYE
ETKTPIMFME NCVYGRDEMM VYHMAETGVL GEIVHCEGGY KHDLREEIAF GRENRHYRLD
NYIHRNSENY PTHELGPIAK ILHINRGNRM LSLCSMASKA AGLRDYIQEK KPEDKVLQNT
VFQQGDIVNT MIHCSNGESI LLTLDTTLPR AYSRGFTVQG TKGMYMEDNA SIFLDGDEGA
KDHFDWKKQW GNVERFRAQY EHPLWKDYLK AGVKKGHGGM DYLVFSEFIH CLQEGLPMPI
DVYDMASWMS ITALSEESIA LGGQAVAIPD FTNGKWIKR
//
