ID   F5XHH0_MICPN            Unreviewed;       310 AA.
AC   F5XHH0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Homocysteine S-methyltransferase {ECO:0000313|EMBL:BAK38178.1};
DE            EC=2.1.1.10 {ECO:0000313|EMBL:BAK38178.1};
GN   Name=mmuM {ECO:0000313|EMBL:BAK38178.1};
GN   OrderedLocusNames=MLP_51640 {ECO:0000313|EMBL:BAK38178.1};
OS   Microlunatus phosphovorus (strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC
OS   101784 / NCIMB 13414 / VKM Ac-1990 / NM-1).
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Microlunatus.
OX   NCBI_TaxID=1032480 {ECO:0000313|EMBL:BAK38178.1, ECO:0000313|Proteomes:UP000007947};
RN   [1] {ECO:0000313|EMBL:BAK38178.1, ECO:0000313|Proteomes:UP000007947}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414
RC   / VKM Ac-1990 / NM-1 {ECO:0000313|Proteomes:UP000007947};
RA   Hosoyama A., Sasaki K., Harada T., Igarashi R., Kawakoshi A., Sasagawa M.,
RA   Fukada J., Nakamura S., Katano Y., Hanada S., Kamagata Y., Nakamura N.,
RA   Yamazaki S., Fujita N.;
RT   "Whole genome sequence of Microlunatus phosphovorus NM-1.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR037505-2};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR037505-2};
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DR   EMBL; AP012204; BAK38178.1; -; Genomic_DNA.
DR   AlphaFoldDB; F5XHH0; -.
DR   STRING; 1032480.MLP_51640; -.
DR   KEGG; mph:MLP_51640; -.
DR   eggNOG; COG2040; Bacteria.
DR   HOGENOM; CLU_004914_3_2_11; -.
DR   Proteomes; UP000007947; Chromosome.
DR   GO; GO:0008898; F:S-adenosylmethionine-homocysteine S-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0061627; F:S-methylmethionine-homocysteine S-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.330; Homocysteine-binding-like domain; 1.
DR   InterPro; IPR017226; Betaine-hCys_S-MeTrfase_BHMT.
DR   InterPro; IPR003726; HCY_dom.
DR   InterPro; IPR036589; HCY_dom_sf.
DR   PANTHER; PTHR46015:SF1; ZGC:171603 PROTEIN; 1.
DR   PANTHER; PTHR46015; ZGC:172121; 1.
DR   Pfam; PF02574; S-methyl_trans; 1.
DR   PIRSF; PIRSF037505; Betaine_HMT; 2.
DR   SUPFAM; SSF82282; Homocysteine S-methyltransferase; 1.
DR   PROSITE; PS50970; HCY; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR037505-2, ECO:0000256|PROSITE-
KW   ProRule:PRU00333};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU00333}; Reference proteome {ECO:0000313|Proteomes:UP000007947};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU00333};
KW   Zinc {ECO:0000256|PIRSR:PIRSR037505-2, ECO:0000256|PROSITE-
KW   ProRule:PRU00333}.
FT   DOMAIN          5..302
FT                   /note="Hcy-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50970"
FT   BINDING         224
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037505-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00333"
FT   BINDING         287
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT   BINDING         288
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
SQ   SEQUENCE   310 AA;  31764 MW;  C7DBE8D6A3EEFE47 CRC64;
     MTGRRRSLAA AIAAGPVLMD GGLGTELESS GCDVTGILWS GQLLLDAPEV VEAAHRRFFA
     AGAQVAISGS YQLSFEGLAA VGVDRAAAET MLRRSVAVAS AAREAAVDPD QTWVAASVGP
     YGATLADGSE FRGTYGKTVT ELQQWHRPRL TVLAEAGADV LAIETIPCLA EVEALLRDID
     GSGVPSWLSL TCASATTTRA GEPVAEAFAM AADVAEVIAV GVNCLPPGDA RDLVATAARS
     SGKPVVVYPN SGEEWDAVHK SWYGDGSLLA GEIAGWLADG ARLVGGCCRV RPAEIEKLAA
     ELSAAESGAA
//