ID F5XVD7_TOXGO Unreviewed; 549 AA.
AC F5XVD7; S8FZB4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 08-NOV-2023, entry version 35.
DE SubName: Full=ROP5_1 {ECO:0000313|EMBL:QDQ69403.1};
DE SubName: Full=ROP5_6 {ECO:0000313|EMBL:QDQ69408.1};
DE SubName: Full=Type II rhoptry protein 5 {ECO:0000313|EMBL:DAA34826.1};
GN Name=ROP5 {ECO:0000313|EMBL:DAA34826.1};
GN Synonyms=rop5_1 {ECO:0000313|EMBL:QDQ69403.1}, rop5_6
GN {ECO:0000313|EMBL:QDQ69408.1};
OS Toxoplasma gondii.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=5811 {ECO:0000313|EMBL:DAA34826.1};
RN [1] {ECO:0000313|EMBL:DAA34826.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ME49 {ECO:0000313|EMBL:DAA34826.1};
RX PubMed=21586633; DOI=10.1073/pnas.1015338108;
RA Behnke M.S., Khan A., Wootton J.C., Dubey J.P., Tang K., Sibley L.D.;
RT "Virulence differences in Toxoplasma mediated by amplification of a family
RT of polymorphic pseudokinases.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:9631-9636(2011).
RN [2] {ECO:0000313|EMBL:QDQ69403.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ME49 {ECO:0000313|EMBL:QDQ69403.1};
RA Oldfield L., Vashee S., Lorenzi H.A.;
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BK008047; DAA34826.1; -; Genomic_DNA.
DR EMBL; MK936474; QDQ69403.1; -; Genomic_DNA.
DR EMBL; MK936474; QDQ69408.1; -; Genomic_DNA.
DR AlphaFoldDB; F5XVD7; -.
DR SMR; F5XVD7; -.
DR VEuPathDB; ToxoDB:TGARI_371740; -.
DR VEuPathDB; ToxoDB:TGCAST_308096; -.
DR VEuPathDB; ToxoDB:TGCOUG_308096; -.
DR VEuPathDB; ToxoDB:TGDOM2_308090; -.
DR VEuPathDB; ToxoDB:TGFOU_360980; -.
DR VEuPathDB; ToxoDB:TGGT1_308093; -.
DR VEuPathDB; ToxoDB:TGMAS_252500; -.
DR VEuPathDB; ToxoDB:TGME49_308090; -.
DR VEuPathDB; ToxoDB:TGP89_360980; -.
DR VEuPathDB; ToxoDB:TGPRC2_308096; -.
DR VEuPathDB; ToxoDB:TGRH88_057710; -.
DR VEuPathDB; ToxoDB:TGRUB_433780; -.
DR VEuPathDB; ToxoDB:TGVAND_252500; -.
DR VEuPathDB; ToxoDB:TGVEG_252500; -.
DR HOGENOM; CLU_462752_0_0_1; -.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR027916; Kinase-like_dom_Apicomplexa.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR016815; Rhoptry_Rop2-like.
DR Pfam; PF14531; Kinase-like; 1.
DR PIRSF; PIRSF022995; Rhoptry_ROP2; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..549
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033972849"
FT DOMAIN 234..527
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 28..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 61102 MW; A4198A9259723249 CRC64;
MATKLARLAT WLVLVGCLLW RAGAVQLSPP NSRTNDLASG TPHVARGDTE AQSGTGDDSD
FPQGVVEEVA DMSGGRVPRV PASSTTTSAS EGIFRRLVRR LRRGRGTADG AGVADETHQG
PRPPLRKRLA QHFRRLRGFF GRLTPRWLSG LGRRAQRWWR GRQRPLLDPS FHGLEAGDSF
MRDLLKREEE LIGYCREEAL KEPAAMVEAV MATVWPQNAE TTVDSLLSQG ERKLKLVEPL
RVGDRSVVFL VRDVERLEDF ALKVFTMGAE NSRSELERLH EATFAAARLL GESPEEARDR
RRLLLPSDAV AVQSQPPFAQ LSPGQSDYAV ANYFFLMPAA SVDLELLFRT LDFVYVFRGE
EGILARHLLT AQLIRLAANL QSKGLVHGRF TPENLFIMPD GRLMMGDVST LRKVGTRGPA
SSVPVTYAPR EFLNANTATF THALNAWQLG LSIYRVWCLV LPFGLVTPGI KRTWKRPSLR
VPGTDSLLFD SCIPVPDFVQ TLTRRFLNFD RRRRLLPLEA METPEFLQLQ NEISSSLSTG
QPTAAPSVA
//
