ID F5YWN5_MYCSD Unreviewed; 524 AA.
AC F5YWN5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Adenylate cyclase {ECO:0000313|EMBL:AEF35322.1};
GN OrderedLocusNames=JDM601_1322 {ECO:0000313|EMBL:AEF35322.1};
OS Mycolicibacter sinensis (strain JDM601) (Mycobacterium sinense).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacter.
OX NCBI_TaxID=875328 {ECO:0000313|EMBL:AEF35322.1, ECO:0000313|Proteomes:UP000009224};
RN [1] {ECO:0000313|EMBL:AEF35322.1, ECO:0000313|Proteomes:UP000009224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JDM601 {ECO:0000313|EMBL:AEF35322.1,
RC ECO:0000313|Proteomes:UP000009224};
RX PubMed=21685274; DOI=10.1128/JB.05291-11;
RA Zhang Z.Y., Sun Z.Q., Wang Z.L., Wen Z.L., Sun Q.W., Zhu Z.Q., Song Y.Z.,
RA Zhao J.W., Wang H.H., Zhang S.L., Guo X.K.;
RT "Complete genome sequence of a novel clinical isolate, the nontuberculous
RT Mycobacterium strain JDM601.";
RL J. Bacteriol. 193:4300-4301(2011).
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002329; AEF35322.1; -; Genomic_DNA.
DR AlphaFoldDB; F5YWN5; -.
DR STRING; 875328.JDM601_1322; -.
DR KEGG; mjd:JDM601_1322; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG3850; Bacteria.
DR HOGENOM; CLU_025433_2_1_11; -.
DR Proteomes; UP000009224; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009224};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 42..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 267..319
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 351..475
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 524 AA; 57174 MW; 6F8DBBD6720ACC4B CRC64;
MGRVLELLTR QTDRLPETPE YGSWLLGRVS ESQYLRRIRI QFILTVVIVG TNLIGIGVEA
LLLAVAFPSP SVFFDAPGWL TYGVVPAYIV LALIFGTYWI TRRTIKKLRW AIREQQPTRV
DERNAFLAPW RVAQVVLALW GVAAMLFTVL YGMADNYFIP IVAFTVGVCG IQVATACYLC
TEFALRPVAA QALAAGPPPR RFFSGIMGRT MMVWLLSSGV PVLGIALTAI FALVLKNLSM
TQFGVAVLVV AVATAVFGFL LMWILSWLTA APVRVVRAAL RRVEQGNLGA DLVVFDGTEL
GELQSGFNAM VHGLRERERV RDLFGRHVGR EVAAAAERDR IQLGGEERHV AVLFVDIIGS
TQIVTAKPAT EVVTLLNRFF AVVVDEVDRH RGLINKFEGD ASLAIFGAPN HLDQPEDEAL
AAGRAILSRL ADEVPEIRAG IGVAAGQVVA GNVGAKERFE YTVIGEPVNE AARLSELAKI
RELQLLTTAR TLRAASISEQ AHWVLGDSVV LRGYDQPTVL AGPL
//
