ID F5YZN0_MYCSD Unreviewed; 540 AA.
AC F5YZN0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Dehydrogenase {ECO:0000313|EMBL:AEF37461.1};
GN OrderedLocusNames=JDM601_3461 {ECO:0000313|EMBL:AEF37461.1};
OS Mycolicibacter sinensis (strain JDM601) (Mycobacterium sinense).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacter.
OX NCBI_TaxID=875328 {ECO:0000313|EMBL:AEF37461.1, ECO:0000313|Proteomes:UP000009224};
RN [1] {ECO:0000313|EMBL:AEF37461.1, ECO:0000313|Proteomes:UP000009224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JDM601 {ECO:0000313|EMBL:AEF37461.1,
RC ECO:0000313|Proteomes:UP000009224};
RX PubMed=21685274; DOI=10.1128/JB.05291-11;
RA Zhang Z.Y., Sun Z.Q., Wang Z.L., Wen Z.L., Sun Q.W., Zhu Z.Q., Song Y.Z.,
RA Zhao J.W., Wang H.H., Zhang S.L., Guo X.K.;
RT "Complete genome sequence of a novel clinical isolate, the nontuberculous
RT Mycobacterium strain JDM601.";
RL J. Bacteriol. 193:4300-4301(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; CP002329; AEF37461.1; -; Genomic_DNA.
DR RefSeq; WP_013830386.1; NC_015576.1.
DR AlphaFoldDB; F5YZN0; -.
DR STRING; 875328.JDM601_3461; -.
DR KEGG; mjd:JDM601_3461; -.
DR eggNOG; COG1053; Bacteria.
DR HOGENOM; CLU_011398_4_2_11; -.
DR OrthoDB; 9813348at2; -.
DR Proteomes; UP000009224; Chromosome.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000009224}.
FT DOMAIN 11..518
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
SQ SEQUENCE 540 AA; 56138 MW; 38C5CAAFF3319032 CRC64;
MTVGDWDDEF DVVVLGTGGA GLTAALTAAV NGASVAVYEK SATVGGTTAV SGGIAWIPAH
TRAPDLTVEA ALDYLRAQSF GAMDDELVST FVRTGQEMVD FVEKHSDVRF EVASGFPDYK
PELPGGRPGG GRSLSPLPYD ISRLGSWQDR ITAFPADYSN VGFDAETRAR LHADIDADTA
AGDLCVAGTA LIAGLLKGAL DHGVTPATGC RGVELIAGSD GGIAGVRVDC GTAARRVRAR
RGVILANGGF EWDTAMVEAF LRGPMRGAVS PPNNTGDALR MAMAHGADLA NMGEAWWVPI
VRIPGDTIDG QQRSRSVRLE RTRPRSIIVN RSGRRFVNEA CDYNSMAGAF HYLEPRGGYV
NDPAWIVFDA EHLRRYGFLG VAPDDAAPEW FCESPDLAAL GARTGIDPDG LAQTVASWNR
GVAAGADPEF GRGASAYDGY WGDDQADTPA GRTLGPLDTA PYYAVPLSVG AMGTKGGPRT
DADGRVLHVT GRPIPGLFAA GNAMAGVTGR AYGGAGGTIG PAMVFGFRAG RAAAAGDSSV
//
