ID F6BEA1_METIK Unreviewed; 108 AA.
AC F6BEA1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit B {ECO:0000256|ARBA:ARBA00015127, ECO:0000256|HAMAP-Rule:MF_01094};
DE EC=2.1.1.86 {ECO:0000256|ARBA:ARBA00012514, ECO:0000256|HAMAP-Rule:MF_01094};
DE AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit B {ECO:0000256|ARBA:ARBA00029818, ECO:0000256|HAMAP-Rule:MF_01094};
GN Name=mtrB {ECO:0000256|HAMAP-Rule:MF_01094};
GN OrderedLocusNames=Metig_1241 {ECO:0000313|EMBL:AEF96778.1};
OS Methanotorris igneus (strain DSM 5666 / JCM 11834 / Kol 5).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanotorris.
OX NCBI_TaxID=880724 {ECO:0000313|Proteomes:UP000009227};
RN [1] {ECO:0000313|EMBL:AEF96778.1, ECO:0000313|Proteomes:UP000009227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5666 / JCM 11834 / Kol 5
RC {ECO:0000313|Proteomes:UP000009227};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Chertkov O., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Pagani I., Sieprawska-Lupa M.,
RA Whitman W., Woyke T.;
RT "Complete sequence of Methanotorris igneus Kol 5.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC translocating step. {ECO:0000256|ARBA:ARBA00002533, ECO:0000256|HAMAP-
CC Rule:MF_01094}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC ChEBI:CHEBI:58319; EC=2.1.1.86;
CC Evidence={ECO:0000256|ARBA:ARBA00001816, ECO:0000256|HAMAP-
CC Rule:MF_01094};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC 2/2. {ECO:0000256|ARBA:ARBA00004839, ECO:0000256|HAMAP-Rule:MF_01094}.
CC -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC MtrE, MtrF, MtrG and MtrH. {ECO:0000256|ARBA:ARBA00011616,
CC ECO:0000256|HAMAP-Rule:MF_01094}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162,
CC ECO:0000256|HAMAP-Rule:MF_01094}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004162, ECO:0000256|HAMAP-Rule:MF_01094}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the MtrB family. {ECO:0000256|ARBA:ARBA00010027,
CC ECO:0000256|HAMAP-Rule:MF_01094}.
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DR EMBL; CP002737; AEF96778.1; -; Genomic_DNA.
DR RefSeq; WP_013799377.1; NC_015562.1.
DR AlphaFoldDB; F6BEA1; -.
DR STRING; 880724.Metig_1241; -.
DR GeneID; 10644104; -.
DR KEGG; mig:Metig_1241; -.
DR HOGENOM; CLU_171544_0_0_2; -.
DR OrthoDB; 114034at2157; -.
DR UniPathway; UPA00640; UER00698.
DR Proteomes; UP000009227; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01094; MtrB; 1.
DR InterPro; IPR008690; MtrB_MeTrfase.
DR NCBIfam; TIGR04166; methano_MtrB; 1.
DR Pfam; PF05440; MtrB; 1.
DR PIRSF; PIRSF005518; MtrB; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01094};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_01094};
KW Methanogenesis {ECO:0000256|HAMAP-Rule:MF_01094};
KW Methyltransferase {ECO:0000256|HAMAP-Rule:MF_01094,
KW ECO:0000313|EMBL:AEF96778.1};
KW One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_01094};
KW Reference proteome {ECO:0000313|Proteomes:UP000009227};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_01094, ECO:0000313|EMBL:AEF96778.1};
KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_01094};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01094}.
FT TRANSMEM 81..99
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01094"
SQ SEQUENCE 108 AA; 12097 MW; C32D03EB0893B28E CRC64;
MEVVKICPEI DVVMEVNSGL VAEMRKDVLV VDLTHVEEEV KKLERLATAL KNSLDPRNPP
LNTFDNRDGV YKISGLFKGM FFGFWITLAI LVLVVILVIK TNLSLIGL
//
