ID   F6DGL4_THETG            Unreviewed;       518 AA.
AC   F6DGL4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase {ECO:0000313|EMBL:AEG33372.1};
DE            EC=1.2.1.8 {ECO:0000313|EMBL:AEG33372.1};
GN   OrderedLocusNames=Ththe16_0955 {ECO:0000313|EMBL:AEG33372.1};
OS   Thermus thermophilus (strain SG0.5JP17-16).
OC   Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=762633 {ECO:0000313|EMBL:AEG33372.1, ECO:0000313|Proteomes:UP000009233};
RN   [1] {ECO:0000313|Proteomes:UP000009233}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SG0.5JP17-16 {ECO:0000313|Proteomes:UP000009233};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Teshima H., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Pagani I., Allgaier M., Hugenholtz P., Singer S.,
RA   Gladden J., Woyke T.;
RT   "Complete sequence of chromosome of Thermus thermophilus SG0.5JP17-16.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP002777; AEG33372.1; -; Genomic_DNA.
DR   RefSeq; WP_014510282.1; NC_017272.1.
DR   AlphaFoldDB; F6DGL4; -.
DR   KEGG; tts:Ththe16_0955; -.
DR   PATRIC; fig|762633.3.peg.951; -.
DR   HOGENOM; CLU_005391_0_1_0; -.
DR   Proteomes; UP000009233; Chromosome.
DR   GO; GO:0018480; F:5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:1901023; P:4-hydroxyphenylacetate catabolic process; IEA:InterPro.
DR   CDD; cd07093; ALDH_F8_HMSADH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR011985; DH_HpaE.
DR   NCBIfam; TIGR02299; HpaE; 1.
DR   PANTHER; PTHR43720; 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43720:SF2; 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:AEG33372.1}.
FT   DOMAIN          38..501
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
SQ   SEQUENCE   518 AA;  57518 MW;  EF578CB4F0EFCA68 CRC64;
     MRYADQVAGI PWETIEAVRR RLKEKPALHF IAGEFSPSES GETFPSLDPA TNEVLGVAAR
     GGEREVDRAA KAAHEAFQRW SRTKAKERKR YLLKIAELIE KHADELAVME CLDAGQVLRI
     VRAQVARAAE NFAFYAEYAE HAMEDRTFPV DRDWLYYTVR VPTGPVGIIT PWNAPLMLST
     WRIAPALAFG NTVVLKPAEW SPFTASKLAE ILQEADLPPG VFNLVQGFGE EAGAALVAHP
     LVPLLTLTGE TETGKIVMRN AAEHLKRLSP ELGGKSPALV FADADLERAL DAVVFQIFSF
     NGERCTASSR LLVEEKIFED FVGRVAERAR AIRVGHPLDP ETEVGPLIHP EHLQRVLGYI
     EAGKQEGARL LVGGERAKTS FRGEDLSRGN YLLPTVFVGE NHMKIAQEEI FGPVLVAIPF
     KDEEDALRKA NDTKYGLAAY VFTRDLERAH RLALELEAGM VYLNSHNVRH LPTPFGGVKQ
     SGDRREGGFY ALDFYTDLKT IALPLRPPHV PKFGKEGR
//