ID F6DHC0_THETG Unreviewed; 575 AA.
AC F6DHC0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:AEG33611.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:AEG33611.1};
GN OrderedLocusNames=Ththe16_1206 {ECO:0000313|EMBL:AEG33611.1};
OS Thermus thermophilus (strain SG0.5JP17-16).
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=762633 {ECO:0000313|EMBL:AEG33611.1, ECO:0000313|Proteomes:UP000009233};
RN [1] {ECO:0000313|EMBL:AEG33611.1, ECO:0000313|Proteomes:UP000009233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SG0.5JP17-16 {ECO:0000313|EMBL:AEG33611.1,
RC ECO:0000313|Proteomes:UP000009233};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Allgaier M., Hugenholtz P., Singer S.,
RA Gladden J., Woyke T.;
RT "Complete sequence of chromosome of Thermus thermophilus SG0.5JP17-16.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000009233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SG0.5JP17-16 {ECO:0000313|Proteomes:UP000009233};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Allgaier M., Hugenholtz P., Singer S.,
RA Gladden J., Woyke T.;
RT "Complete sequence of chromosome of Thermus thermophilus SG0.5JP17-16.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; CP002777; AEG33611.1; -; Genomic_DNA.
DR RefSeq; WP_014510453.1; NC_017272.1.
DR AlphaFoldDB; F6DHC0; -.
DR KEGG; tts:Ththe16_1206; -.
DR PATRIC; fig|762633.3.peg.1198; -.
DR HOGENOM; CLU_009289_1_2_0; -.
DR Proteomes; UP000009233; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000313|EMBL:AEG33611.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transferase {ECO:0000313|EMBL:AEG33611.1}.
FT DOMAIN 48..199
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 250..568
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 575 AA; 62878 MW; E220EC4299E90072 CRC64;
MTGRIHALAL FFALALFLLG LRAWQLQVLE YERYALRSQG NYLKTEDIPA PRGKILDRKG
RVLAQDRLVV DLVYTGGEVA FKERLLPLLG LEDLPQVAEP TVLKAGVPEA LRPTLEELTA
GQKNLYLRER IERYYPNPIS GPVMGYVLRA NAAQVKQGYS PEEEVGQAGL EAALEPYLRG
KRGVRAVEVN VRGERLRETV LEEPTPGQDV VLTLDLALQR AAEKALEEAL ADINAGRRLN
GLPEEKQVKG AIVALDPTTG EVLAMASAPS FDPNLFAKRP VPEEAKALLE DKNLPLLNRA
VQPYTPGSTF KLATSYALLE EGYVTPATTY RCSPYIVFGG QVRRNWASRD MGPMTVREAI
AWSCNTWYYQ AVAQDPLGFV DRLARLAKLL GLGEPTGLEV AEKTGLLPTR AWKREALGEP
WYPGETLSVA IGQGAVLATP AQIARMLATI ATGGNKPALH LVKAIGGVPV QPRWERVPGR
YWKVLQEGLR KTVSEGTARF VLGEFPVPTG GKTGTAETPG KRRGLEHAWY MGYGPTDGSP
YPPLVVVAFF ENGGEGSRVA LPAVRKVMAA YWGIK
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