ID F6DQL7_DESRL Unreviewed; 840 AA.
AC F6DQL7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Diguanylate cyclase {ECO:0000313|EMBL:AEG62014.1};
GN OrderedLocusNames=Desru_3814 {ECO:0000313|EMBL:AEG62014.1};
OS Desulforamulus ruminis (strain ATCC 23193 / DSM 2154 / NCIMB 8452 / DL)
OS (Desulfotomaculum ruminis).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptococcaceae;
OC Desulforamulus.
OX NCBI_TaxID=696281 {ECO:0000313|EMBL:AEG62014.1, ECO:0000313|Proteomes:UP000009234};
RN [1] {ECO:0000313|Proteomes:UP000009234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23193 / DSM 2154 / NCIB 8452 / DL
RC {ECO:0000313|Proteomes:UP000009234};
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Lu M., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Mikhailova N., Pagani I., Stams A.J.M., Plugge C.M., Muyzer G.,
RA Kuever J., Parshina S.N., Ivanova A.E., Nazina T.N., Brambilla E.,
RA Spring S., Klenk H.-P., Woyke T.;
RT "Complete sequence of Desulfotomaculum ruminis DSM 2154.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEG62014.1, ECO:0000313|Proteomes:UP000009234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23193 / DSM 2154 / NCIB 8452 / DL
RC {ECO:0000313|Proteomes:UP000009234};
RX PubMed=23408247; DOI=10.4056/sigs.3226659;
RA Spring S., Visser M., Lu M., Copeland A., Lapidus A., Lucas S., Cheng J.F.,
RA Han C., Tapia R., Goodwin L.A., Pitluck S., Ivanova N., Land M., Hauser L.,
RA Larimer F., Rohde M., Goker M., Detter J.C., Kyrpides N.C., Woyke T.,
RA Schaap P.J., Plugge C.M., Muyzer G., Kuever J., Pereira I.A.,
RA Parshina S.N., Bernier-Latmani R., Stams A.J., Klenk H.P.;
RT "Complete genome sequence of the sulfate-reducing firmicute
RT Desulfotomaculum ruminis type strain (DL(T)).";
RL Stand. Genomic Sci. 7:304-319(2012).
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DR EMBL; CP002780; AEG62014.1; -; Genomic_DNA.
DR RefSeq; WP_013843759.1; NC_015589.1.
DR AlphaFoldDB; F6DQL7; -.
DR STRING; 696281.Desru_3814; -.
DR KEGG; dru:Desru_3814; -.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_70_50_9; -.
DR OrthoDB; 9762141at2; -.
DR Proteomes; UP000009234; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033463; sCache_3.
DR InterPro; IPR029151; Sensor-like_sf.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF17202; sCache_3_3; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009234};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 214..266
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 271..316
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 358..411
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 442..576
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 587..836
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT REGION 820..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 95272 MW; 49654160D80CE161 CRC64;
MGKIRQKVNL FDFHTIRWRI TLVILVVIIF HIATILWITR QVHINATQAA LEKVKGDLQM
GEALLDAHYP GDWMLENGKL CKGNVCMNNN NLIVDKIGRM TGNTCTVFQG DVRIATNIMR
DGSRAIGTKV SKEVAQVVLG EGREYWGEAE VVGIKYQTAY KPIKDSAGKN IGIFYMGANK
QYVDSLFRNC LWNVGATFYL NLLMIVSVVW VLTKSLVRPV RELVHSANRL ARGDLDTKIV
VKAQDEIGYI AKAIERMRKE RKRSEEKLRS AHQQLLNIIE FLPDATFVID QDRRVIAWNR
AVEEMSGVGK EEIIGKGDYA YAKAFYNEAR PILIDLFFFD YPEIRGKYNY IKNKEKTLFA
EIFFPERGDE EGTYWWATAS PLFNDEGKLV GAIESIRDIT EQKVNEKRLE YLATHDSLTS
IPNRFFLEET LKRAVARAKR GRKSALLLID LDNFKMVNDT LGHDAGDRLL LSLTGILRNN
LREEDFLARL GGDEFAVLLE GAAAEEAMVV AEKLRRVIDE SELCLVMYRS CFNVSLSIGI
TLVEGDMPPS RILALADTAL YKAKEGGRNR IAFLRNGEDE TSHFSETNQM VTLIKGALKE
NRFVLYFQPV VSIEGGHIIH YEVLVRMKDT EGELIFPNRF IPVAERFGLM PQIDRWVVES
SLKVLARSPD KKLFINLSGV SLGDEDLLQF IKQAVGENNI DPSRIGFEIT ETAAVKDLSR
AENWISELRK IGCRFSLDDF GIGFSSFYYL KILPVDYIKI DGSFIRNVHQ ENTHSALVQA
INTVAQTLSK KTVAEFVENE EDLKKLQELK VDYAQGYYLG RPEPEECGDA PGSKKPLKDH
//
