GenomeNet

Database: UniProt
Entry: F6GIZ1_LACS5
LinkDB: F6GIZ1_LACS5
Original site: F6GIZ1_LACS5 
ID   F6GIZ1_LACS5            Unreviewed;       667 AA.
AC   F6GIZ1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   SubName: Full=3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring), Pyruvate dehydrogenase (Acetyl-transferring) {ECO:0000313|EMBL:AEH02380.1};
DE            EC=1.2.4.1 {ECO:0000313|EMBL:AEH02380.1};
DE            EC=1.2.4.4 {ECO:0000313|EMBL:AEH02380.1};
GN   OrderedLocusNames=Lacal_2539 {ECO:0000313|EMBL:AEH02380.1};
OS   Lacinutrix sp. (strain 5H-3-7-4).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Lacinutrix.
OX   NCBI_TaxID=983544 {ECO:0000313|EMBL:AEH02380.1, ECO:0000313|Proteomes:UP000008297};
RN   [1] {ECO:0000313|EMBL:AEH02380.1, ECO:0000313|Proteomes:UP000008297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5H-3-7-4 {ECO:0000313|EMBL:AEH02380.1,
RC   ECO:0000313|Proteomes:UP000008297};
RX   PubMed=21725025; DOI=10.1128/JB.05518-11;
RA   Klippel B., Lochner A., Bruce D.C., Walston Davenport K., Detter C.,
RA   Goodwin L.A., Han J., Han S., Hauser L., Land M.L., Nolan M.,
RA   Ovchinnikova G., Pennacchio L., Pitluck S., Tapia R., Woyke T.,
RA   Wiebusch S., Basner A., Abe F., Horikoshi K., Keller M., Antranikian G.;
RT   "Complete genome sequences of Krokinobacter sp. strain 4H-3-7-5 and
RT   Lacinutrix sp. strain 5H-3-7-4, polysaccharide-degrading members of the
RT   family Flavobacteriaceae.";
RL   J. Bacteriol. 193:4545-4546(2011).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP002825; AEH02380.1; -; Genomic_DNA.
DR   AlphaFoldDB; F6GIZ1; -.
DR   STRING; 983544.Lacal_2539; -.
DR   KEGG; lan:Lacal_2539; -.
DR   eggNOG; COG0022; Bacteria.
DR   eggNOG; COG1071; Bacteria.
DR   HOGENOM; CLU_012907_2_1_10; -.
DR   OMA; PMHRNLG; -.
DR   OrthoDB; 9771835at2; -.
DR   Proteomes; UP000008297; Chromosome.
DR   GO; GO:0003863; F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:AEH02380.1}; Pyruvate {ECO:0000313|EMBL:AEH02380.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008297}.
FT   DOMAIN          350..523
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   667 AA;  74605 MW;  BB64C2AA14366BCC CRC64;
     MPNTLMKSNI NYNKTKLSSK TKIALYQAML KPRLIEEKML ILLRQGKISK WFSGIGQEAI
     SVGVTMAMHA EEYILPMHRN LGVFTTRDIP LYRLFSQWQG KANGFTKGRD RSFHFGTQEF
     NIVGMISHLG PQFGVADGIA LASKLKNKNQ VTAVFTGEGG TSEGDIHEAL NVASVWQLPV
     LFCIENNGYG LSTPTKEQYN CENLADRALG YGMESHIIDG NNILEVFTKI SKITESIRKK
     PRPVLIEFKT FRMRGHEEAS GTKYVPQELM DQWAKKDPID NYKLHLLEEG ILTEKEDAIF
     KAEIKAEIDT HLDRTNAEAA IVSTESNELN DVFKSFDYQG VKENKNTEEL RLIDAIHVGL
     KQSMEKHKDL VIMGQDVAEY GGVFKITDGF VEAFGKDRVR NTPICESAII ETAMGLSIAG
     IKSVVELQFS DFVTSGFNPV VNYLAKSHYR WNQNADVVLR MPCGAGVAAG PFHSQTNEAW
     FTKTPGLKVI YPAFPKDAKG LLATAINDPN PVLFFEHKAL YRSIRQDVPT DYFTIPFGKA
     ATLKQGDDIT VIAYGQAVHW ALNTLDKHQD ISADVIDLRS LQPLDTETIY ASAKKTGRVI
     ILQEDSLFGG IASDISALIM ENCFEHLDAP VKRVASLETP IPFINQLEDQ YLARDKFEAE
     LLTLLEY
//
DBGET integrated database retrieval system