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Database: UniProt
Entry: F6HBF5_VITVI
LinkDB: F6HBF5_VITVI
Original site: F6HBF5_VITVI 
ID   F6HBF5_VITVI            Unreviewed;       895 AA.
AC   F6HBF5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=Telomerase reverse transcriptase {ECO:0000256|ARBA:ARBA00016182, ECO:0000256|RuleBase:RU365061};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493, ECO:0000256|RuleBase:RU365061};
DE   AltName: Full=Telomerase catalytic subunit {ECO:0000256|RuleBase:RU365061};
GN   OrderedLocusNames=VIT_13s0064g00980 {ECO:0000313|EMBL:CCB49507.1};
OS   Vitis vinifera (Grape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; Vitales; Vitaceae; Viteae; Vitis.
OX   NCBI_TaxID=29760 {ECO:0000313|EMBL:CCB49507.1, ECO:0000313|Proteomes:UP000009183};
RN   [1] {ECO:0000313|Proteomes:UP000009183}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pinot noir / PN40024 {ECO:0000313|Proteomes:UP000009183};
RX   PubMed=17721507; DOI=10.1038/nature06148;
RG   The French-Italian Public Consortium for Grapevine Genome Characterization.;
RA   Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA   Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA   Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA   Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA   Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA   Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA   Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA   Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA   Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA   Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA   Wincker P.;
RT   "The grapevine genome sequence suggests ancestral hexaploidization in major
RT   angiosperm phyla.";
RL   Nature 449:463-467(2007).
CC   -!- FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the
CC       replication of chromosome termini in most eukaryotes. It elongates
CC       telomeres. It is a reverse transcriptase that adds simple sequence
CC       repeats to chromosome ends by copying a template sequence within the
CC       RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49;
CC         Evidence={ECO:0000256|ARBA:ARBA00024557,
CC         ECO:0000256|RuleBase:RU365061};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}.
CC       Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
CC   -!- SIMILARITY: Belongs to the reverse transcriptase family. Telomerase
CC       subfamily. {ECO:0000256|ARBA:ARBA00008001,
CC       ECO:0000256|RuleBase:RU365061}.
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DR   EMBL; FN595509; CCB49507.1; -; Genomic_DNA.
DR   AlphaFoldDB; F6HBF5; -.
DR   STRING; 29760.F6HBF5; -.
DR   PaxDb; 29760-VIT_13s0064g00980-t01; -.
DR   eggNOG; KOG1005; Eukaryota.
DR   HOGENOM; CLU_001996_0_1_1; -.
DR   InParanoid; F6HBF5; -.
DR   Proteomes; UP000009183; Chromosome 13.
DR   ExpressionAtlas; F6HBF5; baseline.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0000333; C:telomerase catalytic core complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070034; F:telomerase RNA binding; IBA:GO_Central.
DR   GO; GO:0003721; F:telomerase RNA reverse transcriptase activity; IBA:GO_Central.
DR   GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IBA:GO_Central.
DR   CDD; cd01648; TERT; 1.
DR   Gene3D; 1.10.132.70; -; 1.
DR   Gene3D; 1.10.357.90; -; 1.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR021891; Telomerase_RBD.
DR   InterPro; IPR003545; Telomerase_RT.
DR   InterPro; IPR049139; TERT_C.
DR   PANTHER; PTHR12066; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR12066:SF0; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   Pfam; PF12009; Telomerase_RBD; 1.
DR   Pfam; PF21399; TERT_C; 1.
DR   PRINTS; PR01365; TELOMERASERT.
DR   SMART; SM00975; Telomerase_RBD; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU365061};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU365061};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU365061};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU365061};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365061};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009183};
KW   RNA-directed DNA polymerase {ECO:0000256|RuleBase:RU365061};
KW   Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|RuleBase:RU365061};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365061}.
FT   DOMAIN          317..701
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   895 AA;  103367 MW;  5D0B821A4B2807FB CRC64;
     MGEEGGWTPR FLRPFNDWEV EEVERFLSTI QGKRLNADVE DRMVWKETKN EIFTVKSLYN
     SLDHSCAVPF PWSIIWSPYV PTKVGFFCLG SFMGEGSYLR STQKEGYHSL VSLLTLLIRK
     TQSCRHLRLL DKHCAIPSLG RNANENALFM SEVSKSHVHE SKHLKKTLNV LSHQFELNRS
     YCSKSQVISF ISAVCKRIVP SRLLGTPSNW RILRKKISKF VWLRRFEKLS LKQCMHKLKI
     SRFPLLSNKH SSCHLKRWIF WFFSSLVVPL VQANFYVTES EHGKNDLFYY QKSVWEKLTN
     SATTCLKEQS YRSLDDVSVG QILSDRSFGF SRLRFRPKEN GVRALANLNG SSKFRVQDSP
     LKDQSLGMQR KAQLHLERVK FDHFKSVNFV LRDLHAVLKG LQMKEPERLG SSIFDYNDVY
     RKLCPFLISV KNGSTTMPSV FIVVSDVSKA FDSVNQDKLL KVMKDVIVKG KYLLKQSCQV
     VCTRKALWAY ENQILVDQNI GTGLTEFTSS VLSHSLHSVL VNQVRRRTIG SKELYFNLNE
     HVKRNVLQLG NKFYLQNSGI PQGSVLSSLL CSFYYGHMDR NVIFPFLEKT CGPATDYVSG
     KDNCQDVSDA PSSSENNVIT SSPKYMLLRF IDDFLFLSTS KQQAASFFSR LQRGFRDYNC
     YMNEGKFGMN FDIGHISRLS SNRIYVGEDG ISFLRWSGLL INCCSLEVQA DYTRYANSHL
     SSTLTVCWQG RPGRQLKARL FNYMQLRCHP LFYDSNINSA ATVRLNIYQA FLLSAMKFHC
     YTRNLSNICK LQSGYHMEII EKALRRMHTF IKRRMRSMDL DSSFHPILQL KKGEVLWLGL
     KAFIQVLKRK QSRHKELLSL LKSKLLAHPL PETASPELKY AVDDSHSSLL WKIKY
//
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