ID F6HUX6_VITVI Unreviewed; 1275 AA.
AC F6HUX6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=VIT_14s0066g00880 {ECO:0000313|EMBL:CCB58494.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CCB58494.1, ECO:0000313|Proteomes:UP000009183};
RN [1] {ECO:0000313|Proteomes:UP000009183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pinot noir / PN40024 {ECO:0000313|Proteomes:UP000009183};
RX PubMed=17721507; DOI=10.1038/nature06148;
RG The French-Italian Public Consortium for Grapevine Genome Characterization.;
RA Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA Wincker P.;
RT "The grapevine genome sequence suggests ancestral hexaploidization in major
RT angiosperm phyla.";
RL Nature 449:463-467(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR EMBL; FN596252; CCB58494.1; -; Genomic_DNA.
DR AlphaFoldDB; F6HUX6; -.
DR STRING; 29760.F6HUX6; -.
DR PaxDb; 29760-VIT_14s0066g00880-t01; -.
DR eggNOG; KOG0952; Eukaryota.
DR HOGENOM; CLU_000335_0_2_1; -.
DR InParanoid; F6HUX6; -.
DR Proteomes; UP000009183; Chromosome 14.
DR ExpressionAtlas; F6HUX6; baseline.
DR GO; GO:0005694; C:chromosome; IEA:EnsemblPlants.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IBA:GO_Central.
DR CDD; cd18023; DEXHc_HFM1; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009183}.
FT DOMAIN 37..232
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 266..463
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1275 AA; 144599 MW; 55E1787E8A25D868 CRC64;
MSNLDSYSLK SVLDLPVPFQ SAFSFRYFNS LQSECFSACF LSDVNMVISA PTGSGKTVLF
ELCILRLLSR FISEEGRFIH VKGTLKTIYI APSKALVQEK LRDWNQKLGS LGINCLELTG
DNEFYNIRNI QEADIIVTTP EKFDAVTRYR IKDGGLSFFS DIALVLIDEV HLLNDPRGAA
LEAIVSRIKM LARNPEMKLS SLSHVRFLAV SATIPNIEDL AEWLMVPAQG IKRFGEEMRP
VKLTTKVFGY TPAKNDFLFE KRLQNYIFDI LMQYSRGKSA LVFCSTRKGA QEAAQRISQI
AMNYGHSNPF IRSKEQEERL REASLSCSDK QMQSYILYGV GYHNGGLCPK DRNLIEGLFL
KGDIQILCTT NTLAHGINLP AHTVVIKSTQ HFNKEKGLYM EYDRSMILQM CGRAGRPPFE
DTGMAIIMTR RETVHLYENL LNGCELVESQ LLSCVTEHLT AEIVQLTVSD IARAIEWMKC
SYLYVRMKKN PEKYAFKKGI PGNLIEKYTQ DICVQKVNEL SQHQMIWTDE DGFLLKPLEP
GRLMTKYYLK FGTMKHIMQT PLNCSLEDAL HIICRSEEIA WIQLRRNEKK FLNDINMDKD
GQLRFHILGD KGKRKRRIQT REEKIFVLAN DCLTGNPSVH DLSLTQDANA ICSNGCRIAK
CMKEYFIYKK SYKGALNSIL LSKCLLQKLW DDSPYLLKQL PGIGMVTAKA LHSMGIVSFE
ALAEADPRRI EIVTGRKYPF GNHIKESLSS LPPKVELKIE EIECQRQGKS KIVLILTRLS
QSFQSIKRYY ADMVVGLEED NLILFHEKIS RVDEFSSPYS TTILLSTPQQ GKLTVKADLI
FEEYIGIDLH QKLLVVKEIN SNMIHARGSK QLSSFPLPKE VYVIEDDNED ASHSSSKGLD
ISKKSKREMD SLPNFKLIDE ESEEEGSPAI ETEDDECKII TEQTVFEHIR KKSKSFNVLT
KSNASVSPSS EALILTRKRT HEQQLELHVT EALEETERSK IPRRAMVSPF LHSREAELNG
PGISKNSTTK YQPATGSLVV MNFMDDRGAF LFYFIKCYYY YHYSVLYGVL NHLFVSIQAD
LPERTESTSQ IVTENTIFDH IRRKAKNFLV FNKSETPESD STILTKEHFS ENQPVLHEDS
FDTLEGTNSS EALKTTVVIS DSEPKKMEKE SHHVREGAKM DPNIISGSTC STHGSLDPLP
EVSSIQTDPT HIPSFYVARV KNNVQNADPG MCVKNIRKRS LSPNGSKGQC CPAATPGKIR
EVDSFLGFKS VFSFL
//
