ID F6IK70_9SPHN Unreviewed; 386 AA.
AC F6IK70;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Aspartate carbamoyltransferase catalytic subunit {ECO:0000313|EMBL:CCA91888.1};
DE EC=2.1.3.2 {ECO:0000313|EMBL:CCA91888.1};
GN ORFNames=PP1Y_AT9487 {ECO:0000313|EMBL:CCA91888.1};
OS Novosphingobium sp. PP1Y.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=702113 {ECO:0000313|EMBL:CCA91888.1, ECO:0000313|Proteomes:UP000009242};
RN [1] {ECO:0000313|EMBL:CCA91888.1, ECO:0000313|Proteomes:UP000009242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sp. PP1Y {ECO:0000313|Proteomes:UP000009242};
RX PubMed=21685292; DOI=10.1128/JB.05349-11;
RA D'Argenio V., Petrillo M., Cantiello P., Naso B., Cozzuto L., Notomista E.,
RA Paolella G., Di Donato A., Salvatore F.;
RT "De novo sequencing and assembly of the whole genome of Novosphingobium sp.
RT strain PP1Y.";
RL J. Bacteriol. 193:4296-4296(2011).
CC -!- FUNCTION: Reversibly catalyzes the transfer of the carbamoyl group from
CC carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to
CC produce L-citrulline. {ECO:0000256|ARBA:ARBA00003822}.
CC -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC superfamily. {ECO:0000256|RuleBase:RU003634}.
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DR EMBL; FR856862; CCA91888.1; -; Genomic_DNA.
DR AlphaFoldDB; F6IK70; -.
DR KEGG; npp:PP1Y_AT9487; -.
DR eggNOG; COG0540; Bacteria.
DR HOGENOM; CLU_043846_1_2_5; -.
DR UniPathway; UPA00070; UER00116.
DR Proteomes; UP000009242; Chromosome.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR PANTHER; PTHR45753:SF6; ASPARTATE CARBAMOYLTRANSFERASE; 1.
DR PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00101; ATCASE.
DR SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009242};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003634}.
FT DOMAIN 73..209
FT /note="Aspartate/ornithine carbamoyltransferase carbamoyl-P
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02729"
FT DOMAIN 227..371
FT /note="Aspartate/ornithine carbamoyltransferase Asp/Orn-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF00185"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 386 AA; 42896 MW; 83C830AFAE786842 CRC64;
MVRRHRAGTG RPAHPRHRAG RDLVTLPASR VDHAPAIVKR PGKIGNCPNP VDFIAKSPKL
KLHVLDQLRG ASVLSAAQFD KDLLCELAKF AAYLQLKRFE VGRAMDDKIM AAAFFEPSTR
TRLSFESAML HLGGKTISVA DGKTTGVAKG ESMRDIGQMF NSYADVVVVR HTEQSAVSEM
CEYLRVPLLN GGNGSDEHPT QALADWYALL KWRPEIAWAS LPEKFRLNIG IIGTPGNMRT
VKSFLMLALL FHENINHITI FSEMADPLGE ELRELTKNSP IGIDFSQNLQ QSLEYLDVIY
MNAIAYLGDG YRFFGDAFSL NDKSRLKDDT VILHPLARGE ELDVSLDDTQ HNLYFNQADG
AVWIRQALLL AIFGRVAEVV PAELLA
//
