ID F6JVR7_HBV Unreviewed; 354 AA.
AC F6JVR7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:ADN87668.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ADN87668.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ADN87668.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=08/H_377 {ECO:0000313|EMBL:ADN87668.1};
RX PubMed=21311172; DOI=10.1159/000323521;
RA Ismail A.M., Samuel P., Eapen C.E., Kannangai R., Abraham P.;
RT "Antiviral resistance mutations and genotype-associated amino acid
RT substitutions in treatment-naive hepatitis B virus-infected individuals
RT from the Indian subcontinent.";
RL Intervirology 55:36-44(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; GU799054; ADN87668.1; -; Genomic_DNA.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..254
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADN87668.1"
FT NON_TER 354
FT /evidence="ECO:0000313|EMBL:ADN87668.1"
SQ SEQUENCE 354 AA; 39990 MW; F13D93DA897ECAE0 CRC64;
EDWGPCTEHG EHHIRIPRTP ARVTGGVFLV DKNPHNTAES RLVVDFSQFS RGDHRVSWPK
FAVPNLQSLT NLLSSNLSWL SLDVSAAFYH LPLHPAAMPH LLVGSSGLSR YVARLSSNSR
IFNHQRGTMQ NLHDYCSRNL YVSLLLLYQT FGRKLHLYSH PIILGFRKIP MGVGLSPFLL
AQFTSAICSV VRRAFPHCLA FSYMDDVVLG AKSVQHLESL FTAVTNFLLS LGIHLNPNKT
KRWGYSLNFM GYVIGCYGSL PQDHIIQKIK ECFRKLPVNR PIDWKVCQRI VGLLGFAAPF
TQCGYPALMP LYACIQSKQA FTFSPTYKAF LCKQYLNLYP VARQRPGLCQ VFAD
//
