ID F6LC42_9HIV1 Unreviewed; 843 AA.
AC F6LC42;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AEF12304.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AEF12304.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AEF12304.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21593147; DOI=10.1128/JVI.00268-11;
RA van Gils M.J., Bunnik E.M., Boeser-Nunnink B.D., Burger J.A.,
RA Terlouw-Klein M., Verwer N., Schuitemaker H.;
RT "Longer V1V2 Region with Increased Number of Potential N-Linked
RT Glycosylation Sites in the HIV-1 Envelope Glycoprotein Protects against
RT HIV-Specific Neutralizing Antibodies.";
RL J. Virol. 85:6986-6995(2011).
RN [2] {ECO:0000313|EMBL:AEF12304.1}
RP NUCLEOTIDE SEQUENCE.
RA van Gils M., Bunnik E., Schuitemaker H.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; HQ902000; AEF12304.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 2.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AEF12304.1};
KW Virion {ECO:0000313|EMBL:AEF12304.1}.
FT TRANSMEM 499..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..152
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 176..498
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 517..706
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 706..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..730
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEF12304.1"
SQ SEQUENCE 843 AA; 95116 MW; 15006A11091527DE CRC64;
CASDAKAHRT EMHNVWATHA CVPTDPNPQE VLLENVTENF NMWKNDMVEQ MHEDIISLWE
QSLKPCVKLT PLCVTLNCTS NLTECESENG KLNCTKRLKN GTTWGQMENV GEIKNCSFNT
TTGVRDKMQK EYALFYTLDI VQIGDNSDSS SSSSNCSSLD TVNNSTQGNC SGHGNYNSYR
LTHCNTSSIT QACPKVSFEP IPIHYCAPAG FAILKCNDES FSGKGPCKNV STVQCTHGIR
PVVSTQLLLN GSLAEKVVIR SENFTNNAKT IIVHLNQTVN ITCIRYNNNT RKGIHIGPGR
AFYATGDIVG DIRQAHCNIS KEKWNNTLTQ IATKLREQLN ITNITFAPSS GGDPEIVTHS
FNCGGEFFYC NTTQLFNSTL YWNSTNSTWY WNNTRNGGDT ITLPCRIKQV INMWQEVGRA
MYAPPIRGII RCSSNITGLL LTRDGGKNSS DNETFRPGGG DIRDNWRSEL YKYKIVKIEP
LGLAPTKAKR RVVQREKRAV TLGAMFLGFL GAAGSTMGAA SITLTVQARL LLSGIVQQQN
NLLRAIEAQQ HMLQLTVWGI KQLQARVLAV ERYLKDQQLL GIWGCSGKLI CTTAVPWNTS
WSNKSLDTIW NNMTWMEWER EIDNYTGLIY SLLEESQNQQ EKNEQELLEL DKWASLWNWF
NITQWLWYIK IFIMIVGGLI GLRIVFTVLS IVNRVRKGYS PLSFQTHLPA QRGPDRPEGI
EGEGGERDRD GSSRLVHGFL ALIWDDLRSL CLFSYHRLRD LLLIVARVAE LLGRRGWEAL
KYCWNLRQYW SQELKNSAIS LLNAIAIAVA EGTDRIIEIA QAIFRAIIHI PRRIRQGFER
ILL
//
