ID F6LD25_9VIRU Unreviewed; 815 AA.
AC F6LD25;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 22-FEB-2023, entry version 43.
DE SubName: Full=Nsp1a {ECO:0000313|EMBL:AED89601.1};
OS Bovine astrovirus B170/HK.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC Stellavirales; Astroviridae; Mamastrovirus.
OX NCBI_TaxID=1027244 {ECO:0000313|EMBL:AED89601.1, ECO:0000313|Proteomes:UP000143766};
RN [1] {ECO:0000313|EMBL:AED89601.1, ECO:0000313|Proteomes:UP000143766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B170/HK {ECO:0000313|EMBL:AED89601.1};
RX PubMed=21508185; DOI=10.1099/vir.0.030817-0;
RA Tse H., Chan W.M., Tsoi H.W., Fan R.Y., Lau C.C., Lau S.K., Woo P.C.,
RA Yuen K.Y.;
RT "Rediscovery and genomic characterization of bovine astroviruses.";
RL J. Gen. Virol. 92:1888-1898(2011).
CC -!- FUNCTION: Protein covalently attached to the 5' extremity of the
CC genomic and subgenomic RNAs. {ECO:0000256|ARBA:ARBA00029406}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC Evidence={ECO:0000256|ARBA:ARBA00024586};
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DR EMBL; HQ916314; AED89601.1; -; Genomic_RNA.
DR RefSeq; YP_009010953.1; NC_023632.1.
DR GeneID; 18505592; -.
DR KEGG; vg:18505592; -.
DR OrthoDB; 507at10239; -.
DR Proteomes; UP000143766; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR045836; Astro_VPg.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR Pfam; PF19416; Astro_VPg; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 147..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 789..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 90382 MW; E5B6B78D5099980D CRC64;
MSRYINRADE ALASHDRAQL KPRFDAREWF DEMRRIAPTV PWYVVYKPRS YFYPTRTDVP
EPQAVLTAST VCEGEWRTFI MDTQSGRPVM IEVNHILDHQ PTILAAALIH DRAEKSKTIS
ELRLDNELLR GQIAFMRQEY ATTTPRFTMS WATLFALVFL GFSLFWHSAH GLTTTSTTDS
VNPMEMLKLN IWLEDFISAA KRTIHTHHCT VVNAVKASPS WILATAVMPY LWQVVALVLG
VVSVYRAERR VISILFLAAA TISGADWVFL ASASLQTVPS ALIQVACVII SHFDPIGAIC
VSALAMFGTF LASMCATNTT FVQHSRAASA NTAILVLSIV LRTLGLPSMP IALALAIVRA
YTILTTPLGA TIEVRSEDGK VLSKDPLKPG ILFRFKQGLK KFAQLRTSMP PLVRVNPTAV
VRIETPEGVG SGFLCANYIV TAGHVVGQNK VVSICVGSAK YQAPVARQLD GKDVALLKIP
QQMQGYPRLK IAQKVDPEWI CVYSPDDDGA IVQSVVPGHQ VDECLDYAVP TRNGMSGCPV
VNPDGRVMGV HLTNTGFTGG AQIITQADVI DPPKVSTNED KLRQEIDDLK RQLAKCSQSS
SQNEVVELVR AAMAREMKIL RAELNKEIYT QAKGKTKGKK RLRMVGAKTR RQRGPMFTEE
EYQALLEKGM TPEEIRDMVE RLYEKEAAGF PDWDPMDDGY DPDEDWAFES DLNFGQRRVV
VSSFNQYLDR DYDAKAVEDM LRSLTHADVE AIGPLYPITA KCIGTPLCSA ILCLVDRYAV
SSGLSAPTQG LPYTQRRLPK NGKRGPQQRP QKSTN
//
