ID F6MZB9_MNELE Unreviewed; 1461 AA.
AC F6MZB9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE Flags: Fragment;
OS Mnemiopsis leidyi (Sea walnut) (Warty comb jellyfish).
OC Eukaryota; Metazoa; Ctenophora; Tentaculata; Lobata; Bolinopsidae;
OC Mnemiopsis.
OX NCBI_TaxID=27923 {ECO:0000313|EMBL:AEF59086.1};
RN [1] {ECO:0000313|EMBL:AEF59086.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21576472; DOI=10.1073/pnas.1106363108;
RA Liebeskind B.J., Hillis D.M., Zakon H.H.;
RT "Evolution of sodium channels predates the origin of nervous systems in
RT animals.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:9154-9159(2011).
RN [2] {ECO:0000313|EMBL:AEF59086.1}
RP NUCLEOTIDE SEQUENCE.
RA Ryan J.F., Pang K., Mullikin J.C., Martindale M.Q., Liebeskind B.J.,
RA Hillis D.M., Zakon H., Baxevanis A.D.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JF905563; AEF59086.1; -; Genomic_DNA.
DR EnsemblMetazoa; ML358826a-RA; ML358826a-PA; ML358826a.
DR HOGENOM; CLU_000540_5_0_1; -.
DR OMA; SCAPNLN; -.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF62; SODIUM CHANNEL PROTEIN 60E; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132}; Transport {ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 84..102
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 530..553
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 581..601
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 613..637
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 820..843
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 849..872
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 910..929
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1073..1095
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1107..1126
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1170..1196
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1262..1286
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 83..291
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 406..644
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 780..992
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1043..1295
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 314..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEF59086.1"
SQ SEQUENCE 1461 AA; 166588 MW; 9536D30FF4648168 CRC64;
FLSGAAFRSG SRKQRRNLDA CKKQPEITQA IGFRDDDSPK TFSLVNKRMG KKVFFRFSKE
KSLFFLSYTN PIRRFCIRLI CTQWFDHFII AVILINCVLL AADEEQIYVE YAFAVIYTIE
MLLKVFARGF VFHKHAYLRD PWNRLDFVVV LFGYLTLVEE LKNLSFIKAL RVLRSLRTIT
VVPGLRIMVN SLLKSLKNLS DVMLLTLFFL AVFAIIGLQL FMGQLKYRCI TKPEEDSEHM
NFRGTRQCPA PHACLQTDIN PNDGYTSFDN FGFAMLTCAQ LITLDFWEDV YGKSGLPKLD
DDGDECSFVE EDEYDPVDGE NHDQNHHEDG DVGLRPKQPE PRGFFGAMKS CCCCTSEPLQ
SSTHGMDPEN GTMALNLTPS KETCCDKFID VWTWFRSHIK SFIYSFWFEN GIMMCIVINT
LCLALDSPNI SDELDGVLSK VNDCLTWIFT TELVIKLVGL LPTEFWKTKW NIFDTIIVVV
SLVELHLDTS TSFNVSGLRS LRVLRVFRLA KSWSTMKALI DIIAESISGL VYLSIILGVV
IYTLSVIGMN LFIDPYKQYY DNKTANPDSY GTMPRWNYKD FYHSFILLFR ILCGEWIELL
YETLNATKGQ QWPVLFYLGA LVLGNFLVLN LFLALLLNAF GEESIKEKSG ASADVAEGSV
SLTIKIKNKI FNLRKKKHKL ASEIRMSSLA LSPADHMKSP CKHRGKPNGN PSDVEGTNNN
NNNKAENEHD GEDYMSSIDE HEGHDRYSCD DCCQCCMICC RPFCVCCSRF RAAVRRVVEH
RAFEWTILFL IMASSLTLAF EDITLEKAPV RKQIVEILNL FYVVVFTIEM CLKLFAFGVI
TYFESAWHWI DSLVVAISIV SIVVKNVGYG GLKAIRALRA LRPLRAISQW EGMRLSVNAL
ISSIPSFGNV SLVCLVLWLV FCILGVQFFG NKFYKCYKDD DPLEKTEEAF LEHNITTKND
CIAKYGEEAW RNSKINFDNT VMAFFALYQV YEEKGQLGVL LTPAQRRWMS TFRKMAKTKP
IRMVTRPTNK FMKFCYDMSE NQKFEVVITI IILLNMVQMS MEHDSASPEF NNAMVYANYV
FTVIYTLEAI LKIIGTRKFY FYKSWNIFDF VIVVFAWLGI AMDSVMSESV IDPSILRSFR
VFRVARILRI IQMAKGIRRL LYTLICSLPA LINIGTLLLL IIYIYAVVGV AMFGYVRRQG
TLNDQVNFER TPAAIVLMTR LATSAGWNDV LDAIMVSPPD CDANLYESAG GSSGDCGFKG
FAIAYFSSFV LIAFLIMINM YIAVILDNFS EAQQADEIGI DEDDINLFYE KWKVFDPKAT
QFLNVSKLRD LVGQLSQPLG IPEVTEDDIL QLDIPLYPSD RAHCIDVLQA LISRTLGPNN
NTDEFDMIKE LMAESFRAAF PTLAAEVVET TTKQRLREIR AAIVLQKAFR RFKNYKRNEA
LEGIQQTKTG SPESASRHPK V
//
