ID F6NKM9_DANRE Unreviewed; 993 AA.
AC F6NKM9; A0A8M3AUC4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Protein NLRC3 {ECO:0000313|RefSeq:XP_009294058.1};
DE SubName: Full=Si:dkey-222h21.1 {ECO:0000313|Ensembl:ENSDARP00000118953};
GN Name=si:dkey-222h21.1 {ECO:0000313|Ensembl:ENSDARP00000118953,
GN ECO:0000313|RefSeq:XP_009294058.1,
GN ECO:0000313|ZFIN:ZDB-GENE-081031-21};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000118953};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000118953}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000118953};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000118953, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000118953};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_009294058.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009294058.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR769768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009294058.1; XM_009295783.3.
DR STRING; 7955.ENSDARP00000118953; -.
DR PaxDb; 7955-ENSDARP00000118953; -.
DR Ensembl; ENSDART00000140754; ENSDARP00000118953; ENSDARG00000092500.
DR Ensembl; ENSDART00000140754.4; ENSDARP00000118953.2; ENSDARG00000092500.4.
DR GeneID; 794765; -.
DR KEGG; dre:794765; -.
DR AGR; ZFIN:ZDB-GENE-081031-21; -.
DR ZFIN; ZDB-GENE-081031-21; si:dkey-222h21.1.
DR eggNOG; ENOG502SBIG; Eukaryota.
DR HOGENOM; CLU_002274_0_1_1; -.
DR OMA; TRECVIF; -.
DR TreeFam; TF351088; -.
DR Reactome; R-DRE-9758274; Regulation of NF-kappa B signaling.
DR Proteomes; UP000000437; Chromosome 1.
DR Bgee; ENSDARG00000092500; Expressed in granulocyte and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 186..320
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 797..992
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 993 AA; 114278 MW; EE0FAC9904B865FA CRC64;
MKRPESPESS SVSMKSGRSM EQPMRFSDDP MISDPRINRQ RLESSEFSSV SVMSGRSMEQ
PMRFSDAPVT SDPRKCQNQR HMIQENTETV LQRQTLETGD LQRVKDQHKT SMKRKYERLF
EGITLQETGT HLSQIYTQLY ILEGESEGVN EEHEVLQMEK TARTKHSQHT PIYCNDIFKE
EKEQIKTVLT KGIAGIGKTV SVQKFILDWA EGKANQDVDF MFVLPFRELN LIRDHQYSLH
TLLLDFHPEL EDLEPKIYEE CKVVFIFDGL DESRITLMFS DAQKVCDVTE TSSVAVLMSK
LMKGELLPSA LIWITSRPAA ANQIPSKYIK RLTEIQGFTE PQKEEYFRKR ISEQHQASRI
ISHIRRARSL HIMCHIPVFC WISSTVLQKL LEEDLSAEIP QTLTEMYIHF LLIQINMRNQ
KYEERDPEKL LQSNREVIVK LAEVAFRQLM KGNVMFYEED LIESGVDVSD ASVYSGICTE
IFKEESVIQQ RKVYSFIHLS VQEFLAALYV FYYHISNTAE ASLDSLHNLQ IRAVDKAIES
ENGHLDLFLR FLLGVSLESN QRLFQDLLTH TEKSSESIRR STQYIKEKIR DGHGLSTERS
INLFLCLLEV KDQTLSREIQ EFVKSDKQSE KKLSPAHCST IAYMLQMSEE VLDELELHKY
NTSDEGRRRL IPAVSNCTRA LLAGCNLSAQ DCEIVSSVLQ SSNCVLRELD LSNNDLQDSG
VKLLSDGLKS PNCQLEILRL SGCMVTEEGC GFLSSALSSN PSHLRELDLS YNHPGQSGVQ
LLQHTLEDPH YTLQKLNLDH GGHLRIRRGL RKYAVFLTLD PNTAHTQLIL SEGNRKAEFV
KEHQPYPDHP DRFEHHEQVL CKETLTGRCY WEAEWSSWSY IAVTYRGINR KGGSDSWFGY
NDKSWSMYCT DDRFTVWHNN RKTDIPALSK SKRLGVYVDV PSGSLSFYSV SDTHTLTLIH
TLNTTFTEPL YAGFRVFETT LTLCQIKQQH KTQ
//
