ID F6PHJ1_HORSE Unreviewed; 1713 AA.
AC F6PHJ1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Sodium leak channel, non-selective {ECO:0000313|Ensembl:ENSECAP00000015596.2};
GN Name=NALCN {ECO:0000313|Ensembl:ENSECAP00000015596.2,
GN ECO:0000313|VGNC:VGNC:20553};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015596.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000015596.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015596.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000015596.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015596.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9796.ENSECAP00000015596; -.
DR PaxDb; 9796-ENSECAP00000015596; -.
DR Ensembl; ENSECAT00000019071.4; ENSECAP00000015596.2; ENSECAG00000017495.4.
DR CTD; 259232; -.
DR VGNC; VGNC:20553; NALCN.
DR GeneTree; ENSGT00940000156023; -.
DR HOGENOM; CLU_000984_0_0_1; -.
DR InParanoid; F6PHJ1; -.
DR OMA; TLFIAWN; -.
DR OrthoDB; 1110761at2759; -.
DR TreeFam; TF312843; -.
DR Proteomes; UP000002281; Chromosome 17.
DR Bgee; ENSECAG00000017495; Expressed in prefrontal cortex and 9 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005261; F:monoatomic cation channel activity; IBA:GO_Central.
DR GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IBA:GO_Central.
DR GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF1; SODIUM LEAK CHANNEL NALCN; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 855..879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 930..948
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 991..1014
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1108..1131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1185..1205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1211..1230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1250..1268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1310..1332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1397..1421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..331
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 384..588
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 861..1137
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1183..1431
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 736..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1575..1654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 772..801
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1575..1625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1713 AA; 197438 MW; E6DFF146E2928546 CRC64;
MLKRKQSSRV EAQPVTDFGP DESLSDNADI LWINKPWVHS LLRICAIISV ISVCMNTPMT
FEHYPPLQYV TFTLDTLLMF LYTAEMIAKM HIRGIVKGDS SYVKDRWCVF DGFMVFCLWV
SLVLQVFEIA DIVDQMSPWG MLRIPRPLIM IRAFRIYFRF ELPRTRITNI LKRSGEQIWS
VSIFLLFFLL LYGILGVQMF GTFTFHCVVN DTKPGNVTWN SLAIPDTHCS PELEEGYQCP
PGFKCMDLED LGLSRQELGY SGFNEIGTSI FTVYEAASQE GWVFLMYRAI DSFPRWRSYF
YFITLIFFLA WLVKNVFIAV IIETFAEIRV QFQQMWGSRS STTSTATTQM FHEDAAGGWQ
LVAVDVNKPQ GRAPACLQQM MRSSVFHMFI LSMVTVDVIV AASNYHKGES FRRQYDEFYL
AEVAFTVLFD LEALLKIWCL GFTGYISSSL HKFELLLVIG TTLHVYPDLY HSQFTYFQVL
RVVRLIKISP ALEDFVYKIF GPGKKLGSLV VFTASLLIVM SAISLQMFCF VEELDRFTTF
PRAFMSMFQI LTQEGWVDVM DQTLNAVGHM WAPVVAIYFI LYHLFATLLK QSEANADTKE
KLPLRLRIFE KFPNRPQMVK ISKLPSDFTV PKIRESFMKQ FIDRQQQDTC CLLRSLPSAS
SSSCDHSKRS AIEDKYIDQK LRKSVFSIRA RNLLEKETAV TKILRACTRQ RMLSGSFEGQ
PAKERSILSV QHHIRQERRS LRHGSNSQRI SRGKSLETLT QDHSNTVRYR NAQREDSEIK
MIQEKKEQAE MKRKVQEEEL RENHPYFDKP LFIVGREHRF RNFCRVVVRA RFNASKTDPV
TGAVKNTKYH QLYDLLGLVT YLDWVMIIVT ICSCISMMFE SPFRRVMHAP TLQIAEYVFV
IFMSIELNLK IMADGLFFTP TAVIRDFGGV MDIFIYLVSL IFLCWMPQNV PAESGAQLLM
VLRCLRPLRI FKLVPQMRKV VRELFSGFKE IFLVSILLLT LMLVFASFGV QLFAGKLAKC
NDPNIIRRED CNGIFRINVS VSKNLNLKLR PGEKKPGFWV PRVWANPRNF NFDNVGNAML
ALFEVLSLKG WVEVRDVIIH RVGPMHGIYI HVFVFLGCMI GLTLFVGVVI ANFNENKGTA
LLTVDQRRWE DLKSRLKIAQ PLHLPPRPDN DGFRAKMYDI TQHPFFKRTI ALLVLAQSVL
LSVKWDVEDP VTVPLATMSV VFTFIFVLEV TMKIIAMSPA GFWQSRRNRY DLLVTSLGVV
WVVLHFALLN AYTYMMGACV IVFRFFSICG KHVTLKMLLL TVVVSMYKSF FIIVGMFLLL
LCYAFAGVVL FGTVKYGENI NRHANFSSAG KAITVLFRIV TGEDWNKIMH DCMVQPPFCT
PDEFTYWATD CGNYAGALMY FCSFYVIIAY IMLNLLVAII VENFSLFYST EEDQLLSYND
LRHFQIIWNM VDDKREGVIP TFRVKFLLRL LRGRLEVDLD KDKLLFKHMC YEMERLHNGG
DVTFHDVLSM LSYRSVDIRK SLQLEELLAR EQLEYTIEEE VAKQTIRMWL KKCLKRIRAK
QQQSCSIIHS LRESQQQERT RFLNPPSIET TQPSEDMNAN SQDNNMQPET SSQQQLLSPT
LSDRGGSRQD AADAAGKPQR KIGQWRLPSA PKPISHSVSS VNLRFGGRTT MKSVVCKMNP
MTDTASCGSE VKKWWTRQLT VESDESGDDL LDL
//
