ID F6PIW0_HORSE Unreviewed; 441 AA.
AC F6PIW0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Leucine rich repeat containing 17 {ECO:0000313|Ensembl:ENSECAP00000008193.2};
GN Name=LRRC17 {ECO:0000313|Ensembl:ENSECAP00000008193.2,
GN ECO:0000313|VGNC:VGNC:52405};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008193.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000008193.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008193.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000008193.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008193.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6PIW0; -.
DR SMR; F6PIW0; -.
DR STRING; 9796.ENSECAP00000008193; -.
DR PaxDb; 9796-ENSECAP00000008193; -.
DR Ensembl; ENSECAT00000010598.3; ENSECAP00000008193.2; ENSECAG00000010291.4.
DR VGNC; VGNC:52405; LRRC17.
DR GeneTree; ENSGT00940000156400; -.
DR HOGENOM; CLU_049990_0_0_1; -.
DR InParanoid; F6PIW0; -.
DR OMA; RQTQECK; -.
DR OrthoDB; 5397338at2759; -.
DR Proteomes; UP000002281; Chromosome 4.
DR Bgee; ENSECAG00000010291; Expressed in synovial membrane of synovial joint and 19 other cell types or tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048539; P:bone marrow development; IEA:Ensembl.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF210; CHAOPTIN-RELATED; 1.
DR Pfam; PF13855; LRR_8; 2.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 3.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 2.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT DOMAIN 163..213
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 350..401
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 23..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 51822 MW; 4E707945B4881377 CRC64;
MRVAIIVILL FFCKAAELRK ASPRGGRSRA PHGRVAGGRS GSNPVKRYAP GLPCEVYTYL
HEKYLDCQER KLVYVLPGWP QDLLHMLLAR NKIRILKSSM FSKFKKLKSL DLQQNEISKI
DNEAFFGLNK LTTLLLQHNQ IKVLTEEVFL YTPLLSYLRL YDNPWSCTCQ METLVSMLQI
PRNRNLGNYA KCESPPELKN KKLRQIKSEQ LCSEEEKERV DPKPQVSGRP PVIKPEADST
LCYNYVFPIQ TLDCKRKELK KVPNNIPPDI VKLDLSYNKI KLLRPKEFED VHELKKLNLS
SNGLEFIDPA AFLGLTHLEE LDLSNNSLQN FDYGVLEDLY FLKLLWLRDN PWRCDYHIHY
LYYWLRHHYN VHYNGLECKM PEEYKGWFVG KYVRSYYEEC PKDKLPAYPE IFDQDTEEEE
WEKIHKDHTA KKQSVRITIV G
//
