ID F6PJU3_HORSE Unreviewed; 2009 AA.
AC F6PJU3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Sidekick cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSECAP00000015068.4};
GN Name=SDK1 {ECO:0000313|VGNC:VGNC:22775};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015068.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000015068.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015068.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000015068.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015068.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSECAT00000018468.4; ENSECAP00000015068.4; ENSECAG00000016545.4.
DR VGNC; VGNC:22775; SDK1.
DR GeneTree; ENSGT00940000157747; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000016545; Expressed in synovial membrane of synovial joint and 16 other cell types or tissues.
DR ExpressionAtlas; F6PJU3; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 12.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 17.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF30; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 12.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 12.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 7.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 12.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1806..1829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 155..243
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 248..338
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 342..431
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 436..525
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 532..628
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 633..729
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 734..832
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 870..969
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 974..1072
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1077..1174
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1178..1272
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1277..1374
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1379..1497
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1502..1598
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1599..1697
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1700..1798
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1583..1602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1873..1896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1914..1942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2009 AA; 221187 MW; 0F25077C328778B3 CRC64;
MHNDSELTTY TSEYKYIIPS LQRLDAGFYR CVVRNRMGAL LQRRSEVQVA YMGNFMDTDQ
RKTVSQGHAA ILNLLPITSC PRPQVTWFRE GHKIIPSNRI AITLENQLVI LAAAASDSGP
YYVQAVNERN GENKTSPLIY LSVARDVGTP ETMAPVIVIT PGNRSVVAGS SEVTLECIAN
ARPVEDLSVS WKRNGVRITS GLHSFGRHLT ISNPTSSDTG VYVCEATLRG SAFEPARAKA
FLSIIEPPYF TAEPESRILV EVEETVDIVC QAMGVPLPTL QWYKDAISIS KLQNPRYKVL
SSGGLRIQKL RPEDSGIFQC FATNEGGEIQ THTYLDVTNV APAFTQLPVD TTVTDGMTAI
LKCEVSGAPK PAIMWKRGNH ILASGSVRIP RFMLLESGGL QITPVFIQDA GNYTCYAANT
EGSLNASAAL TVWNRTSIIN PPEDRVVIKG TTATLDCGAT HDPRISLRYV WKKDNVVITP
SSSSRIVVEK DGSLLISQTW SGDIGDYTCE IISEGGNDSR MARLEVIELP HSPQNLLASL
NSAHSHTVML SWVRPFDGNS PVLYYIVELS ENNSPWKVHL SNVGPEMTGV AVRGLTPART
YQFRVCAVNQ VGKGQYSTET SRLMLPEEPP SAPPKNIVAS GRTNQSIMVQ WQPPPETEHN
GVLRGYILRY RLAGLPGEYQ QRNITSPEVN YCLVTELIIW TQYEIQVAAY NGAGLGVFSR
AVTEYTLQGV PTAPPQNVQA EAVNSTTIQF LWNPPPQQFI NGINQGYKLL AWPADVPEAS
TVVTIAPDFH GVHHGYITNL KKFTAYLTSV LCFTTPGDGP PSAPQLIWTH EDKPGAVGHL
SFTEILDTSL KVSWQEPLEK NGVITELPGA PSNLVISNIS PRSATLQFRP GYDGKTSISR
WIIEGQVGAI GDEEEWVSLY EEENEPDAQM LEIPNLTPYT HYRFRMRQVN IVGASPFSQS
SRVIQTLQAP PDVAPTSLTV RTASETSLRL RWVPLPDSQY NGNPESVGYR IKYWRPDLQS
PALTQVINDR LEREFTIEEL EEWTEYELQM QAFNAIGAGP WSEVVRGRTR ESVPSAAPEN
VSAEAVSSTQ ILLTWASVPE QDQNGLILGY KILFRAKDLD PEPRSHVVRG NHTQSALLAG
LRKFVLYELQ VLAFTRIGNG VPSSPLVLER TKDDAPGPPV RLVFPEVRLT SVRIVWQPPE
EPNGIILGYQ IAYRLASSSP NTFTTVEVGA TVRQFTATEL APESAYIFRL SAKTRQGWGE
PLEATVITTE KRERPAPPRE LLVPQAEVTA RSLRLQWVPG SDGASPIRYF TVQVRELPRG
EWQTYSSSIS HEATACEVER LRPFTSYKLR LKATNDIGDS DFSVETEAVT TLQDVPGEPP
SFISVTPHTT SSVLIQWQPP RDESLNGLLQ GYRIYYRELE YEAASATESK TLKTPSALRA
ELTAQSSFKT VNSSSTLTTY ELTHLRKYRR YEVVMTAYNI IGESPASAPV EVFVGEAAPA
LAPQNVQVNP LTASQLEVTW DPPPPESQNG NIQGYKIYYW EADSRNETEK MKVLFLPETA
VKLKNLTSHT KYLVSISAFN AAGDGPKSDP RQGHTHEAAP GTPSFLAFSE ITSTTLNVSW
GEPLAANGIL QGYRVVYEPL APVQGVSKVV TVDVKGNRQR WLKVRDLTKG VTYFFRVQAR
TITYGPELQA NVTAGPAEGS PGAPRHISVT KAASELTLQW TEGDAGKAPT TGYVIEARPS
DEGLWDMFAK DIPRSATSYT VSLDRLRQGV TYEFRVVAVN QVGYGEPSRP STAVSAQVET
PFYEEWWFLL VMALSSLIII LLVVFALVLH GQNKKYKNCT TGKSLSNMEE SVTLDNGGFA
ALELNSRHLN VKNTFSKKNG TRSPPRPSPG GLHYSDEDIC NKYNGAVLTE SMNLKEKSVD
ASESEGTDSE SEDAPPQHSF VNHYMSDPTY YNSWKRRAPG GRAAPHRYEA VAGAEAGPPL
HAVVTTQSAV FAPAGPGART PLTGFSSFV
//
