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Database: UniProt
Entry: F6PM16_MONDO
LinkDB: F6PM16_MONDO
Original site: F6PM16_MONDO 
ID   F6PM16_MONDO            Unreviewed;      1743 AA.
AC   F6PM16;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   27-SEP-2017, entry version 46.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1D {ECO:0000313|Ensembl:ENSMODP00000015703};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000015703, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000015703, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000015703}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000015703}.
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DR   STRING; 13616.ENSMODP00000015703; -.
DR   Ensembl; ENSMODT00000015993; ENSMODP00000015703; ENSMODG00000012546.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; F6PM16; -.
DR   OMA; LIQVERP; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000002280; Chromosome 6.
DR   Bgee; ENSMODG00000012546; -.
DR   GO; GO:1990454; C:L-type voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0051393; F:alpha-actinin binding; IEA:Ensembl.
DR   GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0086059; F:voltage-gated calcium channel activity involved SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:1901016; P:regulation of potassium ion transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF239; PTHR10037:SF239; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01636; LVDCCALPHA1D.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    133    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    170    190       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    202    221       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    274    297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    353    374       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    386    408       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    545    563       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    583    606       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    675    694       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    747    774       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    910    928       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    940    959       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    980   1006       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1026   1056       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1151   1178       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1230   1250       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1262   1281       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1374   1397       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1465   1489       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1623   1657       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      777    811       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1743 AA;  197866 MW;  E71500BC8140C891 CRC64;
     MMMMMKKMHP PRREEEEEEH AKEANYARGT RNSLSGDRPT FRPKSSQNSQ QTVLSWQAAI
     DAARQAKAAQ SMSASTPQPV GSLSQRKRQQ YAKSKKQGSS SSSRPARALF CFSLNNPIRR
     ACISIVEWKP FDIFILLAIF ANCVALAVYI PFPEDDSNST NHNLEKVEYA FLIIFTVETF
     LKIIAYGLLL HPNAYVRNGW NLLDFVIVIV GLFSVILEQL TKETEGGNHS SGKSGGFDVK
     ALRAFRVLRP LRLVSGVPSL QVVLNSIIKA MVPLLHIALL VLFVIIIYAI IGLELFIGKM
     HKSCFFTDTD ILAEDDPAPC AFSGNGRQCT SNGTECRSGW VGPNGGITNF DNFAFAMLTV
     FQCITMEGWT DVLYWVNDAI GWEWPWVYFV SLIILGSFFV LNLVLGVLSG EFSKEREKAK
     ARGDFQKLRE KQQLEEDLKG YLDWITQAED IDPENEDEGG DENKRSTSMP TSETESVNTE
     NIGGEGENQG CCGRLWVCRL HCSSVQSVLV FVSFSQAISK SKLSRRWRRW NRFNRRRCRA
     AVKSVSFYWL VIVLVFLNTL TISSEHYNQP DWLTQIQDIA NKVLLAMFTC EMLVKMYSLG
     LQAYFVSLFN RFDCFVVCGG ITETILVELE IMSPLGISVF RCVRLLRIFK VTRHWTSLSN
     LVASLLNSMK SIASLLLLLF LFIIIFSLLG MQLFGGKFNF DETQTKRSTF DNFPQALLTV
     FQILTGEDWN AVMYDGIMAY GGPSSSGMIV CIYFIILFIC GNYILLNVFL AIAVDNLADA
     ESLNTAQKEE AEEKERKKTA RKESLENKKN DKPEVNPMAN SDHKVIIDDY RGEDEDKDPY
     PPCDVPVGEE EEEEEEEDEP EVPAGPRPRR ISELNMKEKI IPIPEGSAFF ILSKTNPIRV
     GCHRLINHHI FTNLILVFIM LSSASLAAED PIRSHSFRNI ILGYFDYAFT AIFTVEILLK
     MTTFGAFLHK GAFCRNYFNL LDMLVVGVSL VSFGIQSSAI SVVKILRVLR VLRPLRAINR
     AKGLKHVVQC VFVAIRTIGN IMIVTTLLQF MFACIGVQLF KGKFYRCTDE AKSNPEECRG
     LFILYKDGDV NSPMVRERVW QNSDFNFDNV LSAMMALFTV STFEGWPALL YKAIDSNGEN
     VGPIYNYRVE ISIFFIIYII IVAFFMMNIF VGFVIVTFQE QGEKEYKNCE LDKNQRQCVE
     YALKARPLRR YIPKNPYQYK FWYVVNSSPF EYMMFVLIML NTLCLAMQHY EQSKIFNDAM
     DILNMVFTGV FTVEMVLKVI AFKPKHYFTD AWNTFDALIV VGSVVDIAIT EVNPTDSENI
     PVPVPTAAPG NSEESNRISI TFFRLFRVMR LVKLLSRGEG IRTLLWTFIK SFQALPYVAL
     LIAMLFFIYA VIGMQMFGKV AMKDNNQINR NNNFQTFPQA VLLLFRCATG EAWQEIMLAC
     LPGKRCDPES DYSPGEEFTC GSNFAIVYFI SFYMLCAFLI INLFVAVIMD NFDYLTRDWS
     ILGPHHLDEF KRIWSEYDPE AKGRIKHLDV VTLLRRIQPP LGFGKLCPHR VACKRLVAMN
     MPLNSDGTVM FNATLFALVR TALKIKTEGN LEQANEELRA VIKKIWKKTS MKLLDQVVPP
     AGDDEVTVGK FYATFLIQDY FRKFKKRKEQ GLVGKYPAKN TTIALQAGLR TLHDIGPEIR
     RAISCDLQDD EPEEKKQEEE EDGFKVIIAN TALYCPLGNV GAGRPALRIC ASGTAFWAPR
     LSL
//
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