ID F6PMV1_MONDO Unreviewed; 2896 AA.
AC F6PMV1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=RAN binding protein 2 {ECO:0000313|Ensembl:ENSMODP00000003555.4};
GN Name=RANBP2 {ECO:0000313|Ensembl:ENSMODP00000003555.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000003555.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000003555.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000003555.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSMODT00000003632.4; ENSMODP00000003555.4; ENSMODG00000002914.4.
DR eggNOG; KOG0864; Eukaryota.
DR eggNOG; KOG0865; Eukaryota.
DR GeneTree; ENSGT00940000154389; -.
DR HOGENOM; CLU_000378_1_0_1; -.
DR TreeFam; TF314797; -.
DR Proteomes; UP000002280; Chromosome 7.
DR Bgee; ENSMODG00000002914; Expressed in extraembryonic membrane and 20 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR GO; GO:0046907; P:intracellular transport; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR CDD; cd14684; RanBD1_RanBP2-like; 1.
DR CDD; cd13177; RanBD2_RanBP2-like; 1.
DR CDD; cd14685; RanBD3_RanBP2-like; 1.
DR CDD; cd13178; RanBD4_RanBP2-like; 1.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 4.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR InterPro; IPR022011; IR1-M.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23138:SF169; E3 SUMO-PROTEIN LIGASE RANBP2; 1.
DR PANTHER; PTHR23138; RAN BINDING PROTEIN; 1.
DR Pfam; PF12185; IR1-M; 2.
DR Pfam; PF00160; Pro_isomerase; 1.
DR Pfam; PF00638; Ran_BP1; 4.
DR Pfam; PF00641; zf-RanBP; 4.
DR PRINTS; PR00153; CSAPPISMRASE.
DR SMART; SM00160; RanBD; 4.
DR SMART; SM00028; TPR; 1.
DR SMART; SM00547; ZnF_RBZ; 4.
DR SUPFAM; SSF50891; Cyclophilin-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 3.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS00170; CSA_PPIASE_1; 1.
DR PROSITE; PS50072; CSA_PPIASE_2; 1.
DR PROSITE; PS50196; RANBD1; 4.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 4.
DR PROSITE; PS50199; ZF_RANBP2_2; 4.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT REPEAT 60..93
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1048..1184
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 1227..1256
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1290..1319
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1354..1383
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1418..1447
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1655..1791
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 1950..2086
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 2583..2718
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 2739..2895
FT /note="PPIase cyclophilin-type"
FT /evidence="ECO:0000259|PROSITE:PS50072"
FT REGION 755..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1625..1650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1914..1948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2197..2219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2375..2512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1635..1650
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1914..1935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2385..2407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2408..2447
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2493..2507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2896 AA; 325136 MW; 3CE797A3E4E8E465 CRC64;
MRRSKAEVER YIASVQGSAP SPREKSMKGF LFAKLYYEAK EYDLAKRYIS TYLNVQERDP
KAHKFLGILY EAEGNIDKAV GCYKRSVELN PTQKDLVLKI AELLCENDAT DGRAKYWVER
ASKLFPGNPT IYRLKEQLLD CKGEDGWNQL FDLIQSELYA RPDDVYVNIR LVELYRSNKR
LKDAVAHCCE AERNLALRTS LEWYSCVVRT LKEYLESLQC LEANKSNWRT TNKDLLLAYA
NLMLLTLSTK DVQESRELLE SFDDALQSVK SFMSGNDELS ITFLEMKGHF YMHAGTLLLK
MAQHSEVQWR ALSELAALCY LIAFQVPRPK TKLMKGDNAG QNLLEMMAYD RLSQTGHMLL
NLSRGKQDFL KEVVESFANK SGQSALYDAL FDSQSPKDKS FLGSDDIRNI SIQTPEPEEL
ARYDIGAIRA HNGSLQHLTW LGLQWSSFST LPAIRKWLKQ LFHHLPQETS RLETNAPESI
CLLDLEVFLL GVIFTSHLQL QEKSSFHYNS HQPPCLPLPV CKQLCTDRQK SWWDAAYNLI
HRKAVSGTSA KLRLLVQHEI NTLRGQGKHG LQPALLVHWA KSLQKTGSGL NSFYDQREYI
GRSVHYWKKV LPLLKTIKKK SNIPEPIDPL FKHFHSADIQ ASEVGEYEEE AHITFAMLDA
VDGKTEDAMS AFEAIKNVVS YWNLALIFHR KAEDIENDAL SPEEREECKN YLRKSRDYLI
KISDESCTDP AVARKLPVPL ESVKEMLNSV MQELEEYSEG GPHCKNGSPR NIDSEIKHST
PSPTKFSLSP SKSYKFSPKT PPRWAEDQNS LLKMICQQVE AIKKEMHELK LNSSNSTISP
HRWPAEAYGT DSMPEGYQGS QNYHGAPLTV ATTGPSVYYS QSPAYNSQYL LRTAANVTPT
KAPVYGMNRL TPQQHIYAYP QQMHTPPVQN PPACMFSQEM YGPPLRFDSP ATGILSPRGD
DYFNYNVQQT NTNPPLPEPG YFTKPPVVPH PSKSVESRVI EFGKSNFGQP LPGPGKSVFG
TPTSDLANKS HDTDGGSAHG DDDDDGPHFE PVVPLPDKIE VKTGEEDEEE FFCNRAKLFR
FDAESKEWKE RGIGNVKILR HKISGKIRLL MRREQVLKIC ANHYINPDMK LTPNAGSDKS
FVWHALDYAD ESPKPEQLAI KFKTPEEAAH FKRKFEEAQG ILRAATSNIS TASQNVRVLK
ETKNQDSKDT AKPDPGHPNF GFQISKKDGL WDCNSCSVKN VATAKKCVSC KNLNPNNKEL
LGPPLVENTP AFKPGTDKTQ EGFGLMFAKK EGHWDCNVCL VRNEPTVSKC IACQNTNTTN
KSTPSFNQQT SFKFGQTDIS KPSTSDLGTL FPKKEGQWNC SVCLVQNEVS AKKCIACQNP
NSQSQPPHTI PAPTALKLST SETSKPTKGG FEGMFMKKEG QWDCTVCLVR NESSALKCVA
CGTPNPVSKP VSEPITETSS DFTFGFKSKL SEPSGSQVVT PFKCDFAEKA FKFGSTEQGF
KFGHSEQGNS PSSFTFQVPS STEAKSTKEG FSFTMPAPAG GFKFGIQESG DQKGSEKSIE
GDAAFKSHDV SNKQTSGDLV FGNSSSTFTF ADLAKSSVGE GFQFGKKDPN FKGFSGAGEK
LFSSQSVKMS PKANTSSDIE KDDDAYKTED NDDIHFEPVV QMPEKVELVT GEEDEKVLYS
QRVKLFRFDA EISQWKERGL GNLKILKNEV NGKLRMLMRR EQVLKVCANH WITTTMNLKP
LSGSDRAWMW LASDFSDGDA KLEQLAAKFK TPELAEEFKQ KFEECQRLLL DIPLQTPHKL
VDTGRAAKLI QRAEEMKSGL KDLKTFLTND KKLTEEENSS SGLAVSASDL TLKPHAETTG
PSLEWDNYDL REDALDDSVS SNSVYASPLT NSPVRKNLFR FGDSTTGFNF SFKSALSPSK
SPAKLNQSRT SVGTDEESDV TQEEEKDGQY FEPVVPLPDL VEVSSGEENE QVVFSHRAKL
YRYDKDAGQW KERGIGDIKI LQNYDNKHVR IVMRRDQVLK LCANHRVTPD MTLQNMKGTE
RVWVWTACDF ADGERKVEQL AVRFKLQDIA DAFKQIFDEA KQAQEKDILL TPHSRAITPR
ESPCGKIAVA VLEETTRERT DLNQGSDMTE TILEIGEVCS TSETPTKAVV SPPKFVFGSE
SVKSIFSSEK SKPFAFGNNS ATGSLFGFSF NAPLKNRSGE DVSGATGRKT EPGKYEPQKN
LDIKPFAENK VEKPLTPFSK GGPSTNYAFK ALEKAEVKKE PEELYTDEVL IVYELTPTPE
QKALAVDLKL PPTFFCYKNR PDYISEEEDD DEDFETAVKK LNGKLYPDDP GECKGSQEFV
AGDVPGHDKE CVIIWEKKPT SDERAKAETL KLPPTFFCGV CSDTDEDSSH QEDFNSEVQK
VQEEKKSQDD DEEEEEEEEE EEEEDEEEEE EEEEEEEEEE EGEEEDVTSS SGTAFTRETK
VPASFICKSE EPDSTTESSD EAHNSSGVND KPVDLSNKKE NEADSTSQEV ESRTLSFGFG
TSTGLSFADL ASGNSGDFAF GSKDKNFQWA NTGATVFGMQ TVSKGGEDEE GSDEEVVHNE
DIHFEPIVSL PEVEVKSGEE DEEILFKERA KLYRWDRDIV QWKERGVGEI KILFHTMKNY
YRILMRRDQV FKVCANHVIT KAMELKSLNV SNNALVWTAT DYADGEAKVE QLAVRFKTKE
MSDNFKKRFE ECQHNLSKLQ KEQVSLVAEL SMETNPVVFF EIFADDEHLG RITIELFSNI
VPLTAENFRA LCTGERGFGF KNSVFHRVIP DFICQGGDIT KHDGTGGRSI YGNTFEDENF
TVRHTGPGLL SMANRGRDTN NSQFFILLKK AEHLDFKHVV FGFVKDGMDT VKKIESFGSP
KGLVSKRIMI TECGQI
//
