ID F6PR90_HORSE Unreviewed; 593 AA.
AC F6PR90;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Kallikrein B1 {ECO:0000313|Ensembl:ENSECAP00000008153.3};
GN Name=KLKB1 {ECO:0000313|Ensembl:ENSECAP00000008153.3,
GN ECO:0000313|VGNC:VGNC:19490};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008153.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000008153.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008153.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000008153.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008153.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; F6PR90; -.
DR MEROPS; S01.212; -.
DR Ensembl; ENSECAT00000010548.3; ENSECAP00000008153.3; ENSECAG00000009884.4.
DR VGNC; VGNC:19490; KLKB1.
DR GeneTree; ENSGT00940000161669; -.
DR HOGENOM; CLU_031604_0_0_1; -.
DR OrthoDB; 5292922at2759; -.
DR TreeFam; TF343687; -.
DR Proteomes; UP000002281; Chromosome 27.
DR Bgee; ENSECAG00000009884; Expressed in liver and 23 other cell types or tissues.
DR ExpressionAtlas; F6PR90; baseline.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd01100; APPLE_Factor_XI_like; 3.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 3.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000177; Apple.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF7; HYALIN; 1.
DR Pfam; PF00024; PAN_1; 3.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00005; APPLEDOMAIN.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00223; APPLE; 3.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50948; PAN; 3.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 1: Evidence at protein level;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F6PR90};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Serine protease {ECO:0000256|RuleBase:RU363034}.
FT DOMAIN 67..150
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 157..240
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 248..331
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 347..582
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 593 AA; 66028 MW; EFB2C88B648E4FAA CRC64;
MWDAYHSIVC QVVPCPYPGS EPVDPGPLKR FGCFLKDSVT GTLPRVSRRS AISGHSLKQC
GHQISACHQD IYKGIDMRGV NFNVSKVNSV EECQKRCTDS IHCQFFTYAT QTFASVEHRN
NCLLKHSPGG TPTSIKVLAN VASGFSLKPC ALSQIGCHMD MFQHLAFSDV DVARVTTPDA
FVCQTICTYN PNCLFFTFYT NAWNIESQRN VCFLKTSQSG TPSSPTPREN TISGYSLLTC
KRTLPEPCHS KIYSGVDFQG EELNVTFVKG ANACQETCTK MVRCQFFTYS LLPEDCRGEK
CKCSSRLSLD GSPTRITHGR QASSGYSLRL CKNEDNSACG TKTNLRVVGG TNSTWGEWPW
QVSLQTMLTT QNHLCGGSII GHQWVLTAAH CFDGLRLSAV WRIYGGILHL SEITKETPFS
QIKEIIIHPN YKISENGHDI ALIKLEVPLN YTESQKPICL PFKDDANTIY TNCWVTGWGY
TKEKGEIQNT LQKANLPLVT NEECQKRYRD HEITKQMICA GYKEGGKDAC KGDSGGPLVC
KHNGIWHLVG VTSWGEGCAR REQPGVYTKV AEYRDWILEK TQSQDGQSLK SRA
//
