ID F6PRP1_MONDO Unreviewed; 865 AA.
AC F6PRP1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Rho guanine nucleotide exchange factor 33 {ECO:0000313|Ensembl:ENSMODP00000010896.3};
GN Name=ARHGEF33 {ECO:0000313|Ensembl:ENSMODP00000010896.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000010896.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000010896.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000010896.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR AlphaFoldDB; F6PRP1; -.
DR STRING; 13616.ENSMODP00000010896; -.
DR Ensembl; ENSMODT00000011112.3; ENSMODP00000010896.3; ENSMODG00000008757.3.
DR eggNOG; ENOG502RVY2; Eukaryota.
DR GeneTree; ENSGT00940000162759; -.
DR HOGENOM; CLU_757712_0_0_1; -.
DR InParanoid; F6PRP1; -.
DR OMA; LEHANMV; -.
DR TreeFam; TF335627; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000008757; Expressed in cerebellum and 2 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR042849; ARHGEF33.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR46944; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33; 1.
DR PANTHER; PTHR46944:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 270..445
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 143..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 40..67
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 143..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 97872 MW; 9A9181CF4F6CA3AF CRC64;
MPVNSPSTQI YQASKYMSSP NLPPVGARLQ RQDGGIITSL EQLHEKINEM RDVFNSLENK
LQALASELKT GFTEAMQELS RIQHGEYALE EKVKSCRCTM EERVSEMKNS LNYFKEELSN
AMSMIQAITT KQEEMQQKIE QLQQEKRRES RKVKTKKTQK EEHASPAGSA PTQVPESRPA
HVADSNVKGI MGPGVNAATP ETEENLKSCL SADVQTKGPM TPGLWRQPKD SKEWSEEYGS
KDHSDKPKEA AQGRHSSLEN VLCETSLSAK RQTVALELLE SERKYVINIS LVLKIKATFQ
GSDGKRSTKE RSLFPGSLRY LVQQHLDLLH ALQERVLKWP RQGVLGDLFL KLTNDENNFL
DYYVAYLRDL PECISLVHVV VLKEAEEEIK SDLYTLFFHI VQRIPEYLIH LQNVLKFTEQ
EHPDYYLLLV CVQRLRVFIS HYTLLFQCNE DLLIQKRKKL KKSSMVKLYK GLASQSANTG
QDTSSAPGSE AVRDSGGIHS EEILQPYPAA TSPGSAVTHL MPQVKKSQQQ TLMENIQPGK
PCDWEMEGRK HERPENLLAP TQFCTSEQDL KSLAAPLQAI PEMDYDAALP DPVANLERSI
RAPAELLSDS RTFVPSYEEF EYGGEIFTLP APYEEETFQS LPLFEACSPA SSESSLDICF
LRPVSFTMEP ERTEHSVQPL PKSSTSPVSS STYKHEAVHG KTKPLSRSLK EFPRTSTSEG
VTTRLYSTRS SSGSRVQLKQ ERTPQPHITS ATARSSPRNF FPPQRTQSEK QTYLEEIHVE
DNTRFCPKEE RECEQTSFSD QHPSSRDQKG GFRSSFRKLF KKKSSGSEYR EKTNENPSVD
PSPTKQDFFR NQLALANDLD QGTAV
//