ID F6PRP3_ORNAN Unreviewed; 1041 AA.
AC F6PRP3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=DNA helicase B {ECO:0000313|Ensembl:ENSOANP00000009430.3};
GN Name=HELB {ECO:0000313|Ensembl:ENSOANP00000009430.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000009430.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000009430.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000009430.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000009430.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000009430.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6PRP3; -.
DR STRING; 9258.ENSOANP00000009430; -.
DR Ensembl; ENSOANT00000009432.3; ENSOANP00000009430.3; ENSOANG00000005924.4.
DR eggNOG; ENOG502QWCN; Eukaryota.
DR GeneTree; ENSGT00390000006913; -.
DR HOGENOM; CLU_010264_0_0_1; -.
DR InParanoid; F6PRP3; -.
DR OMA; CTKNAYL; -.
DR OrthoDB; 5305157at2759; -.
DR TreeFam; TF336223; -.
DR Proteomes; UP000002279; Chromosome 14.
DR Bgee; ENSOANG00000005924; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0017116; F:single-stranded DNA helicase activity; IBA:GO_Central.
DR GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IBA:GO_Central.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR PANTHER; PTHR43788:SF21; DNA HELICASE B; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13604; AAA_30; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 852..898
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13538"
FT REGION 16..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1041 AA; 117142 MW; BF8EE5A6C46F4F67 CRC64;
MTLRASGRLT LCGALLPDKE PPGGDGHHHD DDDDDSGDEQ QFLDAEEMCG GLLLARCLPP
RRTVIIADEY SQKEIKVYGR FPLVDPWWRM KVEVKLVGSE YWVQGYPSYF LQTHIPDNTK
SIFSLFLHNC GLSNDIKAKF WEWVSEESQL PYPNFKSLVK ALYEFEMDRL LEERKSQKKL
DSLQNEFQGP LKTIAYSTAV LALKFPKIVE FLPILLPSIF ENLLSSGYPE PMFEKMQETL
DSEPWKFGFS KITYREFGLV GCEATWTALC QCKALLETIP VLQKNALITY TKLKQNCSYF
GDTYVEQDRL TRELSKQMAV QDTWHALEFL RDHGIIVCEK ERVALWDLHQ AEKDIAFYID
HLLKIPAWHL GVDVKEVLRS GLSQKAKMAD GDDPRERGPP NGALGVWGTG DGPSGSEGDV
GEGAEGDVEV DEDQQSALEM ICSNPVTVVS GKGGCGKTTI VSRLFSHIRQ MVELEVKKAC
EDFESDRDVP EEWKVFGDHH QGEELSVDKY VEVLLTAPTG KAAGLLRRKT SLHAYTLHQV
NYSFYAWKRS DSPLSWKFSS VRVLVVDEGS LVSVTTFRSV LKLLCQHARL VKLIILGDVR
QLPSIEPGNL LMDMFEAFKT RGCSIELKTN HRAESQVIVD NATRISERKL PNFDAEVKIF
QGLTKPFPSE DRRFVLILLP ADGGDLYSAV NTLLKEGAAL KSAKESQFIA FRRQDCDLIN
ECCCKHYSNH LTRDHKNKML FQCDDKICCT RNANLSDVIE KGPRNCKEAS PSHGDESVLF
RNENSAAPGH GDGKTDRLFE TDTRLCNGEI FFITNDVVDK TSEKRFLTLD NMAGLVVTVD
FRKLQRHCRI KHAWARTIHT FQGSEEQTVV YVVGRAGRQH WQHVYTAVTR GRARVYVIAD
EAQLCQAVHR KSYPRKTRLK QFLQEAFAGR REGQQVPGSP STLHPARRGI AESQGLTMDP
GGGAGDTGQD PVASEAEEEE STLQSKGTKR SVALGSFESP KKGIVQVVEA PSPLVSSRFD
NLSLKNLQPR QLFKTTNNEG Q
//
